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Anterior Cruciate Ligament Injuries clinical trials recruiting in the U.S.
28 studies for Anterior Cruciate Ligament Injuries are recruiting participants at sites across the United States.
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Recently updated studies
Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy
Recruiting
Ages 18 to 55 · All sexes · Updated Sep 25, 2026 · NCT06686680Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
Recruiting
Ages 14 to 45 · All sexes · Updated Sep 15, 2026 · NCT06529692Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
Recruiting
Ages 13 and older · All sexes · Updated Aug 27, 2026 · NCT05965310Virtual Reality Mindfulness Meditation After ACL Reconstruction
Recruiting
Ages 14 to 25 · Women · Updated Aug 17, 2026 · NCT05527171Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction
Recruiting
Ages 18 to 40 · All sexes · Updated Aug 14, 2026 · NCT06975306Quadriceps Strengthening ACL Reconstruction
Recruiting
Ages 13 to 17 · All sexes · Updated Jul 24, 2026 · NCT07015541Gait Rehabilitation to Treat FastOA
Recruiting
Ages 16 to 35 · All sexes · Updated Jun 25, 2026 · NCT05848622MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)
RecruitingEarly phase 1
Ages 25 to 50 · All sexes · Updated Jun 10, 2026 · NCT04572256Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
Recruiting
Ages 14 to 65 · All sexes · Updated Jun 10, 2026 · NCT05461326The Pediatric ALL Evaluation and Trial
RecruitingHealthy volunteers welcome
Up to age 18 · All sexes · Updated May 29, 2026 · NCT04825587Steps Towards Osteoarthritis Prevention
Recruiting
Ages 16 to 40 · All sexes · Updated Apr 29, 2026 · NCT06193343Baseline ACL Injury Risk Screening and Normative Data
RecruitingObservational studyHealthy volunteers welcome
Ages 10 to 65 · All sexes · Updated Apr 17, 2026 · NCT06635668BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures
RecruitingObservational study
Ages 14 to 70 · All sexes · Updated Apr 14, 2026 · NCT06948591Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction
RecruitingPhase 4
Ages 18 to 40 · All sexes · Updated Apr 9, 2026 · NCT06511232Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial
Recruiting
Ages 14 to 39 · All sexes · Updated Apr 1, 2026 · NCT06942754Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry
RecruitingObservational study
Ages 18 to 50 · All sexes · Updated Feb 27, 2026 · NCT04536103PRP in ACLR to Prevent PTOA
RecruitingPhase 3
Ages 14 to 50 · All sexes · Updated Feb 13, 2026 · NCT05412381Biologic Therapy to Prevent Osteoarthritis After ACL Injury
RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 to 35 · All sexes · Updated Jan 26, 2026 · NCT03968913The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial
Recruiting
Ages 12 to 18 · All sexes · Updated Jan 7, 2026 · NCT05754632Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets
Recruiting
Ages 17 to 27 · All sexes · Updated Jan 2, 2026 · NCT06341868Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery
RecruitingHealthy volunteers welcome
Ages 14 to 30 · All sexes · Updated Dec 24, 2025 · NCT05488054Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
RecruitingPhase 4
Ages 18 to 55 · All sexes · Updated Nov 20, 2025 · NCT06311513Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
Recruiting
Ages 14 to 35 · All sexes · Updated Nov 13, 2025 · NCT05949177Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
Recruiting
Ages 16 to 35 · All sexes · Updated May 31, 2025 · NCT04875052A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products
Recruiting
Ages 16 to 65 · All sexes · Updated May 22, 2025 · NCT06979804From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.