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Anterior Cruciate Ligament Injuries clinical trials recruiting in the U.S.

28 studies for Anterior Cruciate Ligament Injuries are recruiting participants at sites across the United States.

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Recently updated studies

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

Recruiting
Ages 18 to 55 · All sexes · Updated Sep 25, 2026 · NCT06686680

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

Recruiting
Ages 14 to 45 · All sexes · Updated Sep 15, 2026 · NCT06529692

Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention

Recruiting
Ages 13 and older · All sexes · Updated Aug 27, 2026 · NCT05965310

Virtual Reality Mindfulness Meditation After ACL Reconstruction

Recruiting
Ages 14 to 25 · Women · Updated Aug 17, 2026 · NCT05527171

Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction

Recruiting
Ages 18 to 40 · All sexes · Updated Aug 14, 2026 · NCT06975306

Quadriceps Strengthening ACL Reconstruction

Recruiting
Ages 13 to 17 · All sexes · Updated Jul 24, 2026 · NCT07015541

Gait Rehabilitation to Treat FastOA

Recruiting
Ages 16 to 35 · All sexes · Updated Jun 25, 2026 · NCT05848622

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

RecruitingEarly phase 1
Ages 25 to 50 · All sexes · Updated Jun 10, 2026 · NCT04572256

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

Recruiting
Ages 14 to 65 · All sexes · Updated Jun 10, 2026 · NCT05461326

The Pediatric ALL Evaluation and Trial

RecruitingHealthy volunteers welcome
Up to age 18 · All sexes · Updated May 29, 2026 · NCT04825587

Steps Towards Osteoarthritis Prevention

Recruiting
Ages 16 to 40 · All sexes · Updated Apr 29, 2026 · NCT06193343

Baseline ACL Injury Risk Screening and Normative Data

RecruitingObservational studyHealthy volunteers welcome
Ages 10 to 65 · All sexes · Updated Apr 17, 2026 · NCT06635668

BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures

RecruitingObservational study
Ages 14 to 70 · All sexes · Updated Apr 14, 2026 · NCT06948591

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

RecruitingPhase 4
Ages 18 to 40 · All sexes · Updated Apr 9, 2026 · NCT06511232

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Recruiting
Ages 14 to 39 · All sexes · Updated Apr 1, 2026 · NCT06942754

Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry

RecruitingObservational study
Ages 18 to 50 · All sexes · Updated Feb 27, 2026 · NCT04536103

PRP in ACLR to Prevent PTOA

RecruitingPhase 3
Ages 14 to 50 · All sexes · Updated Feb 13, 2026 · NCT05412381

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 to 35 · All sexes · Updated Jan 26, 2026 · NCT03968913

Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery

RecruitingHealthy volunteers welcome
Ages 14 to 30 · All sexes · Updated Dec 24, 2025 · NCT05488054

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

RecruitingPhase 4
Ages 18 to 55 · All sexes · Updated Nov 20, 2025 · NCT06311513

Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

Recruiting
Ages 14 to 35 · All sexes · Updated Nov 13, 2025 · NCT05949177

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

Recruiting
Ages 16 to 35 · All sexes · Updated May 31, 2025 · NCT04875052

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.