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Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
Who can join
Ages 18 to 55 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Exclusion Criteria: All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
About the study
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
What is being tested
- Neuropeptide Y (drug)
Sponsor: University of Texas Southwestern Medical Center · Participants: 100 · Started: Jul 18, 2021
Contact the study team
- Christopher M Hearon, Ph.D. · Phone: 214-345-4624
- Mary Childers · Phone: 214-345-6459
Official record on ClinicalTrials.gov — NCT04838678
Locations in the U.S.
| Texas | University of Texas Southwestern Medical Center, Dallas |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.