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Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.
Efficacy of Preoperative Administration of Gabapentin in Managing Intraoperative and Postoperative Pain From Third Molar Extractions.
Who can join
Ages 18 to 59 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Subjects must be at or older than 18. * Screened body mass index (BMI) between 18-35 kg/m2. * American Society of Anesthesiologists Classification I and II. * Subjects must be willing and able to comply with protocol requirements. * Subjects must be able to understand the informed consent and must be able to sign a written informed consent form prior to the initiation of any study procedures. * A subject must have at least 1 partial or fully impacted third molar tooth removal. Exclusion Criteria: * hypersensitivity to gabapentinoids; * history of chronic opioid or gabapentin usage (regular use of opioids \>3 months) * history of recreational drug usage * a history or clinical manifestations of significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urologic, musculoskeletal, psychiatric, or immunologic disorder, any acute, clinically significant illness or condition within 14 days prior to Day 1. * Patients with baseline pain. * Patients with any oral pathology will be excluded. * Pregnant or breastfeeding patients * An individual not legally competent to consent (e.g., incapacitated individuals, incompetents, minors)
About the study
This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing wisdom teeth extraction. We will measure intraoperative opioid use, severity of pain, the number of analgesics taken, and side effect profiles (e.g. nausea/vomiting, dizziness) at the following intervals, 4 hour, 8 hour, 12 hour, 24, and 72 hour post-procedure.
What is being tested
- Gabapentin 600mg (drug)
- Placebo (drug)
Sponsor: Loma Linda University · Participants: 98 · Started: Jun 16, 2021
Contact the study team
- Je Dong Ryu, DMD MD · Phone: 909-558-4423
- Sung Han, DDS MD · Phone: 909-558-4423
Official record on ClinicalTrials.gov — NCT04860141
Locations in the U.S.
| California | Loma Linda University Health, Loma Linda |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.