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Enhancing Language Function in Primary Progressive Aphasia
Enhancing Language Function in Primary Progressive Aphasia (PPA) With Transcranial Direct Current Stimulation (tDCS)
Who can join
Ages 45 to 80 · All sexes
Full eligibility criteria
Inclusion Criteria: * diagnosed with PPA by neurologist or speech-language pathologist * speech-language deficit arising from PPA * native speaker of English Language or equivalent * adequate vision (normal or corrected to normal) * adequate hearing Exclusion Criteria: * meeting (Diagnostic and Statistical Manual) DSM-IV criteria for Axis I mood, anxiety, psychotic or substance abuse disorders. * highly magnetizable metallic implants, including certain dental work * neurological disorders besides the ones of interest for the study (e.g., epilepsy) * Multiple Sclerosis * Parkinson's Disease * contraindications for MRI * pacemakers * metallic cardiac pumps * valves * magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field. * clinically significant claustrophobia * severe systemic disease (e.g., renal failure) * poor health * pregnancy * epileptic activity in the past 12 months * family history of epilepsy or other seizure disorders * brain surgery in the past * metallic skull plates or implants * skin lesions or skull damage * excessive use of alcohol or drugs * premorbid psychiatric disease affecting communication * severe non-linguistic cognitive disturbances impeding language therapy
About the study
This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around damage and improve language functions.
What is being tested
- tDCS + language therapy (combination product)
- sham TDCS + language therapy (combination product)
Sponsor: University of Arizona · Participants: 20 · Started: Aug 30, 2021
Contact the study team
- Aneta Kielar, PhD · Phone: 15204883791
Official record on ClinicalTrials.gov — NCT04920318
Locations in the U.S.
| Arizona | University of Arizona, Tucson |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.