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Primary Progressive Aphasia clinical trials recruiting in the U.S.
18 studies for Primary Progressive Aphasia are recruiting participants at sites across the United States.
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Recently updated studies
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
RecruitingHealthy volunteers welcome
Ages 50 to 80 · All sexes · Updated Sep 9, 2026 · NCT03887481Remotely-supervised Neuromodulation in PPA
Recruiting
Ages 40 and older · All sexes · Updated Sep 4, 2026 · NCT07260253Biofluid Research on Age-Related or Inherited Neurodegeneration
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07798700A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
RecruitingPhase 1/2
Ages 30 to 75 · All sexes · Updated Aug 13, 2026 · NCT06064890Propranolol in Primary Progressive Aphasia
RecruitingEarly phase 1
Ages 50 and older · All sexes · Updated Jul 17, 2026 · NCT06066710Stimulating the Aging Brain Using Brain and Sensory Stimulation
Recruiting
Ages 45 and older · All sexes · Updated Jun 16, 2026 · NCT07650188Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
RecruitingHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Jun 10, 2026 · NCT05741853Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
RecruitingEarly phase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06511752Communication Bridge 3 Study
RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Jun 1, 2026 · NCT06191198Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
RecruitingPhase 2Healthy volunteers welcome
Ages 50 to 90 · All sexes · Updated May 5, 2026 · NCT05386394The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech
RecruitingObservational study
Ages 18 and older · All sexes · Updated May 1, 2026 · NCT03313011Intervention for Communication Quality of Life in Primary Progressive Aphasia
Recruiting
Ages 40 and older · All sexes · Updated Apr 21, 2026 · NCT07219680Language in Primary Progressive Aphasia
RecruitingObservational study
All ages · All sexes · Updated Feb 27, 2026 · NCT00537004UPenn Observational Research Repository on Neurodegenerative Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jan 22, 2026 · NCT04715399Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Nov 12, 2025 · NCT01818661STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners
RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 27, 2025 · NCT06613204Enhancing Language Function in Aphasia
RecruitingHealthy volunteers welcome
Ages 21 to 80 · All sexes · Updated Dec 9, 2024 · NCT05443633Enhancing Language Function in Primary Progressive Aphasia
Recruiting
Ages 45 to 80 · All sexes · Updated Nov 29, 2024 · NCT04920318From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.