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A Study to Evaluate Breathing Muscle Training in Cardiac Rehab

RecruitingHealthy volunteers welcome

Combined Cardiac Rehabilitation and Inspiratory Muscle Training in Heart Failure

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria - Heart Failure Group:

* Adult 18 years and older.
* English speaking.
* Has a qualifying heart failure indication for center-based cardiac rehabilitation.

Inclusion Criteria - Healthy Control Group:

* Adult 18 years and older.
* English speaking.
* Absence of pulmonary, cardiovascular, musculoskeletal, neurologic, or orthopedic diseases. Controls will be matched for age and sex.

Exclusion Criteria:

* HF patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program.
* Participants unable/unwilling to provide informed consent.
* Uremia, history of allergy to iodides. Impaired renal function.
* Creatinine value greater than 1.3 mg/dL (via clinical record within the past 6 months).
* Diagnosis of liver disease.

About the study

The purpose of this study is to understand if breathing muscle training combined with cardiac rehabilitation influences the blood flow and blood pressure response during exercise.

What is being tested

Sponsor: Mayo Clinic · Participants: 42 · Started: Jun 1, 2021

Contact the study team

Official record on ClinicalTrials.gov — NCT04984473

Locations in the U.S.

MinnesotaMayo Clinic in Rochester, Rochester

Conditions

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.