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Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Recruiting

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain.

  * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL).
  * Surgery: drainage procedures (Frey and Puestow operations)

Exclusion Criteria:

* Patients with chronic pain from conditions other than CP
* Patients \< 18 years of age
* Patients who have had endoscopic therapy within the past 12 months
* Patients who have undergone prior pancreatic surgery
* Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy)
* Patients with peripheral sensory deficits
* Patients with known pregnancy at the time of study screening\*\*

  * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.

About the study

Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.

What is being tested

Quantitative Sensory Test 1 (diagnostic test)
Quantitative Sensory Test 2 (diagnostic test)
Quantitative Sensory Test 3 (diagnostic test)

Sponsor: University of Pittsburgh · Participants: 150 · Started: Jan 4, 2022

Contact the study team

Anna Evans Phillips, MD, MS · Phone: 412-647-2345

Official record on ClinicalTrials.gov — NCT04996628

Locations in the U.S.

Indiana	Indiana University Medical Center, Indianapolis
Maryland	Johns Hopkins Medical Institutions, Baltimore
Pennsylvania	University of Pittsburgh Medical Center, Pittsburgh

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.