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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
PANTHER Study: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress
Who can join
Ages 8 to 14 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * HbA1c ≥6.0% for untreated high-risk group * BMI ≥ 85th %ile for high-risk group * Normal HbA1c ≤5.6% for control group * Type 1 diabetes (T1D) Antibody negative Exclusion Criteria: * History of Chronic kidney disease (CKD) or acute kidney injury (AKI) * Metabolic disorder prohibiting safe fasting * Iodine or penicillin allergy * Pregnancy * Thrombophilia * MRI contraindications * Hormone therapy
About the study
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
What is being tested
- Aminohippurate Sodium Inj 20% (drug)
- Iohexol Inj 300 MG/ML (drug)
- Dextran 40 (drug)
Sponsor: Petter Bjornstad · Participants: 100 · Started: Sep 27, 2021
Contact the study team
- Petter Bjornstad, MD · Phone: (206) 616 3543
Official record on ClinicalTrials.gov — NCT05008276
Locations in the U.S.
| Colorado | Children's Hospital Colorado, Aurora |
| Washington | Seattle Children's Hospital, Seattle |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.