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Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

Topical Epidural Steroid Usage in Patients Undergoing Posterior Lumbar Decompression: A Randomized Control Trial

Who can join

Ages 18 to 85 · All sexes

Inclusion Criteria:

* Patients scheduled to undergo 1 to 2 level laminectomy
* Between the ages of 18-85

Exclusion Criteria:

* Minimally invasive surgery
* Prior daily opioid usage within 6 months.
* Use of concomitant procedures such as spinal fusion, revision procedure at the same level.
* History of a chronic pain syndrome, uncontrolled diabetes defined as A1C \> 6.5, immunocompromised condition such as active cancer treatment, history of transplant, benign prostatic hyperplasia or history of urinary retention, and other conditions which require chronic steroid therapy or immunosuppressants.
* Non-English speakers
* Patients allergic to Depo-Medrol and/or glucocorticoids, or other steroids

About the study

This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy. The study will examine post-operative opioid usage, length of stay, return to work, and patient reported outcomes following these procedures.

What is being tested

• Depo-Medrol 40Mg/Ml Suspension for Injection (drug)
• Placebo (drug)

Sponsor: Hospital for Special Surgery, New York · Participants: 150 · Started: Nov 5, 2021

Contact the study team

• Catherine Himo Gang, MPH · Phone: (917) 623-5416

Official record on ClinicalTrials.gov — NCT05058287

Locations in the U.S.

Conditions

• Spinal Stenosis
• Pain After Surgery
• Back Pain

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.