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Influence of Pulse Electromagnetic Field Therapy on Myocardial Ischemia

Recruiting

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Age ≥ 18 years old.
* Known cardiac ischemia, who are non revascularizable, or have not and will not be undergo coronary intervention for the duration of their participation in the study.
* Evidence of ischemia from previous clinical tests (echo, nuclear, standard ECG from past 6 months).
* Left Ventricular Ejection fraction \> 40% by echo (evaluated last 3 months).
* Able to complete a cardiopulmonary exercise test without significant non cardiac limitations, primarily orthopedic.
* On guideline directed optimal therapy for stable ischemia.

Exclusion Criteria:

* Anemia (\< 7 mg/dl).
* Low potassium (\< 3 mmol/L).
* Creatinine (\> 5.0 mg/dl or \< 0.6 mg/dl).
* Unable to exercise due primarily to orthopedic limitation.
* Severe lung disease.
* Morbid obesity (BMI \> 42).
* Pregnant.
* Breast feeding.
* Significant arrhythmia (ventricular tachycardia, ventricular fibrillation, frequent premature ventricular contractions (PVCs), persistent atrial fibrillation, or 2nd or 3rd degree atrioventricular (AV) block).
* Seizures.
* Unstable angina.
* Coronary spasm.
* Recent myocardial infarction (\< 90 days).
* Recent percutaneous coronary intervention (\<90 days).

About the study

This study is being done to observe the effects of treatment from a device called the Bioboosti which utilizes pulsed electromagnetic waves on its ability to improve blood flow to the heart tissue in individuals with coronary artery disease (CAD).

What is being tested

Sponsor: Mayo Clinic · Participants: 120 · Started: May 18, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05111288

Locations in the U.S.

ArizonaMayo Clinic in Arizona, Scottsdale
MinnesotaMayo Clinic in Rochester, Rochester

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.