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Post-Concussion Musculoskeletal Injury Risks

RecruitingObservational studyHealthy volunteers welcome

Post-Concussion Neuromuscular Function and Musculoskeletal Injury Risk

Who can join

Ages 18 to 40 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

Concussed Cohort

* 18-40 years old.
* Self-reported asymptomatic post-concussion following enrollment into the study and monitoring of symptoms by research personnel via daily self-reported symptom questionnaires.
* Recruited within 5 days following being diagnosed with a concussion, and at least 72 hours prior to self-reporting as asymptomatic.
* Access to a functional email address and the internet for completion of patient reported outcomes (PROs) and musculoskeletal injury measures.

Non-Concussed Cohort

* 18-40 years old.
* Active duty Service members and physically active civilians.
* No self-report history of concussion within the previous 5 years.
* No lingering post-concussion signs/symptoms.
* Same gender as the matched concussed participant.
* Within ±5% of the matched concussed participant's height, weight, and body mass index.
* Within ±2 years of age of the matched concussed participant.
* Participant in the same physical activities (work, recreational sports, average type \[no impact, low-impact, high-impact\] and duration of physical activity)

Exclusion Criteria:

* Post-Concussion Cohort AND Healthy Non-Concussed Cohort

  * Unable to read or comprehend the English language.
  * Admitted to the hospital following concussion.
  * Sustained a concussion not related to physical activity participation (e.g., blast-related injury, fall from a ladder, motor vehicle accident).
  * Loss of consciousness longer than 30 minutes.
  * Alteration in consciousness longer than 24 hours.
  * Post-traumatic amnesia lasting longer than 1 day.
  * Glasgow Coma Scale below 13.
  * Abnormal brain imaging findings.
  * Sustained a concussion that took longer than 21 days for the individual to report as asymptomatic.
  * A MSKI within the last 6 months that resulted in altered or missed physical activity for 3 or more consecutive days.
  * History of MSKI surgery.
  * Pregnant females (will be eligible for participation in the study once medically cleared to RTD/A by a qualified and licensed healthcare provider following the end of the pregnancy).
  * Participants will be excluded if they present any known contraindications for electrical stimulation. These contraindications include conditions such as: active deep vein thrombosis/thrombophlebitis, any acute injury with concurrent inflammation, hemorrhagic conditions, impaired circulation, impaired local sensations, presence of infection (osteomyelitis, tuberculosis), malignancy, recently radiated tissue, skin disease/damage and/or at-risk skin.
  * Present with any implanted pacemaker, electronic device, or plastic/cement material

About the study

Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases MSKI risk in physically active individuals, including Service Members.

The overall goal of the study is to identify the neuromuscular control mechanisms that increase MSKI risk following concussion. It is hypothesized that concussed individuals will display abnormal neuromuscular function that increases MSKI risk, as compared to non-concussed controls. The study will employ a multi-center, prospective, case-matched control observational study to identify the differences in neuromuscular function following concussion that may contribute to increased MSKI risk. Once the neuromuscular control mechanisms that increase MSKI risk following concussion are identified, targeted risk mitigation strategies can be developed to reduce MSKI risk.

What is being tested

Sponsor: Walter Reed National Military Medical Center · Participants: 148 · Started: Oct 20, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05122728

Locations in the U.S.

GeorgiaUniversity of Georgia, Athens
MarylandWalter Reed National Military Medical Center, Bethesda

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.