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Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

Who can join

Ages 18 to 80 · All sexes

Inclusion

1. Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist.
2. The ability to comply with test directions, complete pre-operative task training, and provide informed consent.
3. Age 18-80 years.

Exclusion

1\. Inability to understand or perform the task outlined in the protocol during a pre-surgery training session. 2. Significant hearing loss.

3\. Cortical venous anatomy that could potentially obstruct ECoG electrode placement, as determined by the surgeon, visualized on pre-op MRI or during surgery.

About the study

The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.

What is being tested

• Deep Brain Stimulation (procedure)

Sponsor: Massachusetts Eye and Ear Infirmary · Participants: 120 · Started: Jun 21, 2022

Contact the study team

• Kristina Simonyan, MD, PhD · Phone: 617-573-6016

Official record on ClinicalTrials.gov — NCT05150093

Locations in the U.S.

Conditions

• Dysphonia
• Tremor
• Dystonia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.