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A Pilot Study of Total-body PET Using FDA-approved Radiotracers Beyond 18F-FDG

RecruitingObservational study

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
18F-PSMA (n=3) and 68Ga-PSMA (n=3)

Inclusion criteria:

* Persons \>18 yo with suspected prostate cancer metastasis
* Prior imaging study (CT, and/or MRI and/or Bone scan and/or Fluciclovine scan) suspicious for metastatic disease, obtained within 4 months from the research scan date.

  68Ga DOTATATE (n=3) or 64Cu-DOTATATE (n=3)

Inclusion Criteria:

* Persons \> 18 yo suspicious for or diagnosed with somatostatin receptor positive neuroendocrine tumors (NETs)
* Prior DOTATATE PET/CT scan suspicious for tumor obtained not earlier than 4 months from the research scan date.

Exclusion Criteria:

• Recent administration of long-acting somatostatin analogs

Exclusion Criteria for all participants:

* Adults unable to consent
* Pregnant/lactating persons
* Prisoners
* Unable to lie supine for up to 90 minutes at different timepoints in the PET scanner
* Uncontrolled claustrophobia
* Any significant medical condition that in the opinion of the investigator would prevent the participant from participating and/or adhering to study related procedures or interfere with participant safety

About the study

The purpose of this research study is to test new ways to improve the usefulness of the world's first total-body positron emission tomography (PET)/computed tomography (CT) scanner (EXPLORER) by collecting data from PET scans using one of three different imaging agents: 18F-PSMA; 18F-FES; or, 68Ga DOTATATE. These imaging agents are approved by the FDA to be used for patients diagnosed with prostate cancer (18F-PSMA), neuroendocrine tumor (68Ga DOTATATE), or breast cancer (18F-FES).

What is being tested

Sponsor: University of California, Davis · Participants: 9 · Started: Jun 7, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT05160480

Locations in the U.S.

CaliforniaUC Davis EXPLORER Molecular Imaging Center, Sacramento

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.