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The Oxford Risk Factors And Non-Invasive Imaging Study

RecruitingObservational study

Who can join

Ages 18 to 99 · All sexes

Full eligibility criteria
Inclusion Criteria:

Inclusion Criteria for study Arms 1, 2 and 3:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 -99 years.

Inclusion Criteria for study Arm 4:

• Male or Female, aged 18 -99 years.

Exclusion Criteria:

Exclusion Criteria for Study Arms 1, 2 and 3:

* Unable or unwilling to consent
* Active cancer

Exclusion Criteria for Study Arm 4:

* Participation in Study Arms 1, 2 or 3
* Existing opt-out from use of data for research purposes

About the study

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Sponsor: University of Oxford · Participants: 250,000 · Started: Feb 23, 2016

Contact the study team

Official record on ClinicalTrials.gov — NCT05169333

Locations in the U.S.

ArizonaValleywise Health, Phoenix
ConnecticutYale University, School of Medicine, New Haven
FloridaBridging Medical Silos, Tampa
GeorgiaEmory University, Atlanta
KansasMidwest Heart & Vascular Specialists LLC, Kansas City
St Luke's Hospital, Kansas City
MarylandNIH National Heart, Lunch, and Blood Institute, Bethesda
MassachusettsBrigham and Women's Hospital, Boston
OhioCleveland Clinic, Cleveland
TexasUT Southwestern Medical Center, Dallas
Brooke Army Medical Center (BAMC), San Antonio
VirginiaUniversity of Virginia, Charlottesville

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.