Home › Cerebral Palsy › NCT05197946
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Who can join
Ages 8 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Participants with CP (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Diagnosis of cerebral palsy Exclusion Criteria: -None Neurotypical participants: (Survey-only): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis Participants with CP (Survey and MRI): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents * Diagnosis of cerebral palsy * Clinical imaging demonstrating isolated periventricular white matter injury * Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury * Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI Exclusion Criteria: -None Neurotypical participants (Survey and MRI): Inclusion Criteria: * Individual 8+ years of age * Adult subject able to indicate understanding and affirmative consent * Able to lie still in scanner for 1.5 hours and be able to have MRI Exclusion Criteria: -Clinically-significant neurologic or developmental diagnosis
About the study
The investigators hope to use MRI biomarkers to identify and characterize sensorimotor network disruption patterns associated with chronic pain and sensory deficits in CP. Investigators will use existing information in the medical record as well as subjective reports from interview, physical exam data, and anatomical and functional MRI data to non-invasively identify brain injury correlates of pain and sensory deficits.
What is being tested
- MRI (diagnostic test)
Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Participants: 300 · Started: Dec 4, 2018
Contact the study team
- Paul Salib, MS · Phone: (443) 923-9272
- Eric Chin, MD · Phone: (443) 923-9141
Official record on ClinicalTrials.gov — NCT05197946
Locations in the U.S.
| Maryland | F.M. Kirby Center, Baltimore Johns Hopkins Hospital, Baltimore Kennedy Krieger Institute, Baltimore Mt. Washington Pediatric Hospital, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.