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Study of Gastric Motility in Eosinophilic Gastritis
Pilot Assessment to Find Evidence of Gastric Motility Abnormalities in Eosinophilic Gastric Disorders
Who can join
Ages 18 to 59 · All sexes
Full eligibility criteria
Inclusion Criteria: * Eosinophilic gastritis (EG) defined as at least one endoscopy with histopathologic evidence of ≥ 30 eosinophils in 5 or more high powered fields (hpf's) with associated symptoms of EG. * Patient reported symptoms starting at least one year or more prior to screening consistent with a diagnosis of EG: nausea, vomiting, early satiety, abdominal pain/bloating, regurgitation, diarrhea. * Symptoms suggestive of a possible gastric motility disorder during the 60 days prior to screening including: nausea, vomiting, early satiety, post-prandial feeling of fullness or bloating. * Tolerance and willingness to consume the oatmeal meal in this study. Exclusion Criteria: * Diagnosis of eosinophilic enteritis. * Inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis). * Known disorders associated with eosinophilic gastrointestinal (GI) diseases (e.g., D 816 V Kit+ systemic mastocytosis, Marfan syndrome or Loey's Dietz Syndrome). * Known inflammatory or autoimmune disorders associated with gastric dysmotility such as systemic sclerosis, lupus or eosinophilic fasciitis. * Uncontrolled diabetes or known diabetic complications of gastroparesis, neuropathy or nephropathy. * Taking opioid agents in the 2 weeks prior to screening and throughout the study. * History of strictures in the small bowel or stomach (e.g., pyloric stenosis) or gastric surgeries or procedures such as pyloromyotomy, pyloric dilation, pyloric resection, vagotomy, bariatric surgery or post-Nissen fundoplication or antrectomy with Billroth I, Billroth II or Roux-en-Y gastrojejunostomy. * Past or current medical problems or findings such as: advanced liver disease (Child's B or C), acute or chronic renal disease (serum creatinine \> 3 mg/dL), neurologic disease (e.g., dysautonomia), achalasia and adrenal insufficiency.
About the study
Purpose:
The study is a cross-sectional observational study designed to determine if eosinophilic gastritis (EG) results in gastric motility impairment.
Hypothesis:
Gastric dysfunction occurs in the natural history of EG but is underdiagnosed due, in part, to contraindications to the use of the standard meals used in gastric emptying studies.
Sponsor: Children's Hospital Medical Center, Cincinnati · Participants: 30 · Started: Jan 25, 2023
Contact the study team
- Regina Yearout · Phone: (513) 517-2108
Official record on ClinicalTrials.gov — NCT05229432
Locations in the U.S.
| Illinois | Northwestern University, Chicago |
| Maryland | The National Institutes of Health, Bethesda |
| Utah | University of Utah, Salt Lake City |
Conditions
- Gastroparesis
- Eosinophilic Esophagitis
- Eosinophilic Disorders
- Digestive Diseases
- Immune System and Disorders
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.