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Sensory Optimization of the Hospital Environment
Multisensory Interventions to Improve Neurodevelopmental Outcomes of Preterm Infants Hospitalized in the Neonatal Intensive Care Unit
Who can join
1 Day – 7 Days · All sexes
Full eligibility criteria
Inclusion Criteria: * ≤ 32 weeks estimated gestational age (EGA) * recruited within the first week of life Exclusion Criteria: * \> 32 weeks EGA at birth * \>7 days old * become wards of the state * have a suspected or confirmed congenital anomaly * face a high immediate threat of death, per the opinion of the attending physician.
About the study
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often applied in an inconsistent manner, reducing their benefit. Through a rigorous and scientific process, we have developed a structured multisensory intervention program, titled Supporting and Enhancing NICU Sensory Experiences (SENSE), which includes specific doses and targeted timing of evidence-based interventions such as massage, auditory exposure, rocking, holding, and skin-to-skin care. The interventions are based on the infant's developmental stage and are adapted based on the infant's medical status and behavioral cues. The multisensory interventions are designed to be conducted during each day of NICU hospitalization by the parents, who are educated and supported to provide them. The proposed work aims to determine the effect of multisensory interventions on parent mental health, parent-child interaction, brain activity (amplitude integrated electroencephalography), and infant developmental outcomes through age 2 years, with specific attention to language outcome.
What is being tested
- SENSE multisensory program (behavioral)
- Monitored standard of care (behavioral)
Sponsor: University of Southern California · Participants: 215 · Started: May 29, 2023
Contact the study team
- Roberta Pineda, PhD OTR/L · Phone: (323) 442-2850
- Amit Mathur, MD · Phone: 314) 577-5642
Official record on ClinicalTrials.gov — NCT05230199
Locations in the U.S.
| Missouri | Cardinal Glennon Children's Hospital, St Louis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.