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Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study

Tempus CRC Surveillance Study: A Longitudinal Circulating Tumor DNA (ctDNA) Biomarker Profiling Study of Patients With Colorectal Cancer (CRC) Using Comprehensive Next-Generation Sequencing (NGS)Assays

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Known or suspected colorectal adenocarcinoma (Stage I to IVA disease)
* Planning to undergo or has undergone a surgical resection for suspected adenocarcinoma of the colon or rectum with curative intent.
* 18 years old or older
* Willing and able to provide informed consent
* Willing to have additional blood samples collected during routine surveillance visits

Exclusion Criteria:

* Not willing to have additional blood samples collected
* Pathology that is not consistent with colorectal adenocarcinoma

About the study

The study is an observational multicenter evaluation of participants with colorectal cancer (CRC) who will receive longitudinal plasma ctDNA biomarker profiling in addition to their standard-of-care therapy and disease surveillance.

What is being tested

Sponsor: Tempus AI · Participants: 300 · Started: Jun 21, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05234177

Locations in the U.S.

ArkansasMercy Clinic Oncology - Fort Smith, Fort Smith
CaliforniaMemorialCare, Fountain Valley
MarylandThe Center for Cancer and Blood Disorders, Bethesda
MissouriMercy Clinic Oncology and Hematology - Joplin, Joplin
Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center, Springfield
Mercy Clinic Oncology and Hematology - David C. Pratt Cancer Center, St Louis
Mercy Clinic Oncology and Hematology - Sindelar Cancer Center, St Louis
Washington University School of Medicine, St Louis
NebraskaNebraska Cancer Specialists, Omaha
North CarolinaSoutheastern Medical Oncology Center, Goldsboro
OhioAultman Hospital, Canton
TriHealth Cancer Institute, Cincinnati
Ohio State University, Columbus
OhioHealth Research Institute, Columbus
Toledo Clinic Cancer Center, Toledo
OklahomaMercy Clinic Oncology and Hematology - Coletta, Oklahoma City
PennsylvaniaCancer Care Associates of York, York
UtahUtah Cancer Specialists, Salt Lake City
WashingtonUniversity of Washington / Fred Hutchinson Cancer Center, Seattle
WisconsinThedaCare Regional Cancer Center, Appleton

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.