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Colorectal Cancer clinical trials recruiting in the U.S.
332 studies for Colorectal Cancer are recruiting participants at sites across the United States.
Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.
Cities with the most studies
- Houston, TX101 studies
- New York City, NY86 studies
- Nashville, TN67 studies
- Boston, MA62 studies
- Los Angeles, CA61 studies
- Arlington, VA54 studies
- St. Louis, MO51 studies
- San Antonio, TX43 studies
- Philadelphia, PA41 studies
- Grand Rapids, MI40 studies
- Baldwin Park, CA37 studies
- Tampa, FL36 studies
- Seattle, WA35 studies
- Dallas, TX34 studies
- Queens, NY33 studies
- Aurora, CO33 studies
- Chicago, IL32 studies
- Pittsburgh, PA31 studies
- Durham, NC30 studies
- Baltimore, MD30 studies
- Atlanta, GA29 studies
- Portland, OR28 studies
- Washington, DC28 studies
- Rochester, MN27 studies
- Detroit, MI25 studies
- Edison, NJ25 studies
- Cleveland, OH25 studies
- Jacksonville, FL25 studies
- Phoenix, AZ24 studies
- Columbus, OH24 studies
- New Haven, CT23 studies
- Ann Arbor, MI22 studies
- Salt Lake City, UT22 studies
- San Diego, CA22 studies
- Madison, WI22 studies
- Oklahoma City, OK22 studies
- Denver, CO22 studies
- Orlando, FL21 studies
- Cincinnati, OH20 studies
- Minneapolis, MN20 studies
By state
- Alabama11 studies
- Alaska4 studies
- Arizona55 studies
- Arkansas14 studies
- California135 studies
- Colorado55 studies
- Connecticut27 studies
- Delaware9 studies
- District of Columbia16 studies
- Florida99 studies
- Georgia38 studies
- Hawaii5 studies
- Idaho7 studies
- Illinois49 studies
- Indiana24 studies
- Iowa15 studies
- Kansas18 studies
- Kentucky19 studies
- Louisiana17 studies
- Maine4 studies
- Maryland45 studies
- Massachusetts62 studies
- Michigan70 studies
- Minnesota44 studies
- Mississippi6 studies
- Missouri59 studies
- Montana6 studies
- Nebraska22 studies
- Nevada10 studies
- New Hampshire6 studies
- New Jersey38 studies
- New Mexico8 studies
- New York103 studies
- North Carolina47 studies
- North Dakota7 studies
- Ohio62 studies
- Oklahoma22 studies
- Oregon28 studies
- Pennsylvania66 studies
- Rhode Island5 studies
- South Carolina14 studies
- South Dakota12 studies
- Tennessee74 studies
- Texas145 studies
- Utah35 studies
- Vermont5 studies
- Virginia77 studies
- Washington48 studies
- West Virginia6 studies
- Wisconsin35 studies
- Wyoming3 studies
Recently updated studies
A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07693751Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses
Recruiting
Ages 22 and older · All sexes · Updated Nov 13, 2026 · NCT07276529Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06959550Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
Recruiting
Ages 18 and older · Women · Updated Nov 12, 2026 · NCT05649072Zanzalintinib Alone or in Combination With Pembrolizumab and Berahyaluronidase Alfa in Participants With Colorectal Cancer With Molecular Residual Disease
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07750158Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
RecruitingPhase 1
Ages 18 to 120 · All sexes · Updated Nov 12, 2026 · NCT04847063Evaluation for NCI Surgery Branch Clinical Research Protocols
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT00001823Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06878131A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07659795Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07500298A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06270706A KRAS Inhibitor in Participants With Advanced Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07912593Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer
RecruitingPhase 2
Ages 18 to 72 · All sexes · Updated Nov 12, 2026 · NCT01174121Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07775287A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07458347A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06004245Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04739072A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07020221Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT04557449A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07503808Role of Diet on the Microbiome of the Digestive System
RecruitingObservational study
Ages 45 and older · All sexes · Updated Nov 10, 2026 · NCT04666727Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT06102902Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
RecruitingPhase 1/2Mentions payment for participants
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06149481Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
RecruitingPhase 1
Ages 12 to 120 · All sexes · Updated Nov 9, 2026 · NCT04222413A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04929223From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.