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Colorectal Cancer clinical trials recruiting in the U.S.

332 studies for Colorectal Cancer are recruiting participants at sites across the United States.

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

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Recently updated studies

A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07693751

Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses

Recruiting
Ages 22 and older · All sexes · Updated Nov 13, 2026 · NCT07276529

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06959550

Evaluation for NCI Surgery Branch Clinical Research Protocols

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT00001823

Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06878131

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07659795

A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06270706

A KRAS Inhibitor in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07912593

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

RecruitingPhase 2
Ages 18 to 72 · All sexes · Updated Nov 12, 2026 · NCT01174121

Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT04739072

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07020221

Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT04557449

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07503808

Role of Diet on the Microbiome of the Digestive System

RecruitingObservational study
Ages 45 and older · All sexes · Updated Nov 10, 2026 · NCT04666727

Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

RecruitingPhase 1/2Mentions payment for participants
Ages 18 to 120 · All sexes · Updated Nov 9, 2026 · NCT06149481

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

RecruitingPhase 1
Ages 12 to 120 · All sexes · Updated Nov 9, 2026 · NCT04222413

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.