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Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

RecruitingHealthy volunteers welcome

Who can join

Ages 18 to 120 · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* Patient Inclusion Criteria

  * Hospitalized patients (age ≥ 18 years) with high-risk AML defined as:
  * Patients with new diagnosis ≥ 60 years of age
  * An antecedent hematologic disorder
  * Therapy related-disease
  * Relapsed or primary refractory AML
  * Within five business days of initiating therapy with either a) intensive chemotherapy (7+3) or modification of this regimen on a clinical trial, or a similar intensive regimen requiring prolonged hospitalization; or b) hypomethylating agents +/- additional agents or modification of this regimen on a clinical trial.
* Caregiver Inclusion Criteria

  * Adult (≥18 years) relative or friend of a participating patient who the patient identifies as living with or has in-person contact with them at least twice per week.

Exclusion Criteria:

\- Patient Exclusion Criteria

* Patients with a diagnosis of acute promyelocytic leukemia (APML)
* Patients with AML receiving supportive care alone
* Patients with psychiatric or cognitive conditions which the treating clinicians believe prohibits informed consent or compliance with study procedures
* Patients seen by a palliative care clinician (MD, DO, APP) during two previous hospitalizations in the six months prior to enrollment
* Patients expected to be discharged within 2 days

About the study

This research study is evaluating whether primary palliative care is an alternative strategy to specialty palliative care for improving quality of life, symptoms, mood, coping, and end of life outcomes in patients with acute myeloid leukemia (AML).

What is being tested

Sponsor: Massachusetts General Hospital · Participants: 2,300 · Started: Jun 1, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05237258

Locations in the U.S.

AlabamaUniversity of Alabama - Birmingham, Birmingham
CaliforniaStanford University, Stanford
ColoradoUniversity of Colorado Denver I Anschutz Medical Campus, Denver
FloridaUniversity of Miami, Miami
Moffitt Cancer Center, Tampa
GeorgiaEmory University, Atlanta
IllinoisNorthwestern University, Evanston
IndianaIndiana University, Bloomington
MarylandJohns Hopkins University, Baltimore
MassachusettsDana-Farber Cancer Institute, Boston
Massachusetts General Hospital, Boston
MinnesotaMayo Clinic, Rochester
New YorkUniversity of Rochester, Rochester
North CarolinaUniversity of North Carolina at Chapel Hill, Chapel Hill
Duke University, Durham
OhioOhio State University, Columbus
OregonOregon Health & Science University, Portland
PennsylvaniaUniversity of Pennsylvania, Philadelphia
WashingtonFred Hutchinson Cancer Center, Seattle
WisconsinUniversity of Wisconsin, Madison

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.