Study of Low-intensity Focused Ultrasound Effects on Heat Evoked fMRI Signals
RecruitingHealthy volunteers welcome
Who can join
Ages 18 to 65 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Healthy volunteers, all ethnicities, who understand and speak English. Exclusion Criteria: Claustrophobia (scanning environment may be uncomfortable). Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. Contraindications to CT: pregnancy Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's) History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor) History of head injury resulting in loss of consciousness for \>10 minutes. History of alcohol or drug dependence (through self-report).
About the study
Study of LIFU on fMRI pain signals. Participants receive low-intensity focused ultrasound (LIFU) and fMRI scans to measure changes in both resting and heat pain signals. Physiology may also be measured. Questionnaires and symptom monitoring will take place. The study takes place over 4 study visits.
What is being tested
- Neuromodulation with low-intensity focused ultrasound (other)
Sponsor: Virginia Polytechnic Institute and State University · Participants: 80 · Started: May 6, 2022
Contact the study team
- Jessica W Florig, MPH · Phone: 540-526-2261
Official record on ClinicalTrials.gov — NCT05303415
Locations in the U.S.
| Virginia | Fralin Biomedical Research Institute, Roanoke |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.