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Reducing Pain From Wisdom Molar Extractions
Non-randomized Prospective Pilot Study on Effect of Temporo-masseteric Nerve Block (TMNB) on Pain Reduction Following Wisdom Molar Extractions
Who can join
Ages 18 to 64 · All sexes
Full eligibility criteria
Inclusion Criteria: * Age 18 years of age or older (up to 64 years) * Any demographic * ASA 1 and 2 (mild or absent systemic illnesses, deemed fit for undergoing dental extractions under intravenous sedation) * Not pregnant (as will not qualify to undergo procedure under intravenous sedation as part of routine standard-of-care) * Adequate mental ability to understand and provide informed consent * Has smart phone and internet connection Exclusion Criteria: * Age older than 64 years (because they are poor candidates for undergoing procedures under intravenous sedation) * Pregnant * Incapable of providing informed consent * Any systemic condition that renders the patient at higher risk for complications under intravenous sedation * Documented allergy to the dental local anesthetic * Inability to tolerate any of the commonly used pain medications such as combination opioids, acetaminophen (Tylenol®) or ibuprofen (Motrin® or Advil®) * Limitation in adequate mouth opening in presence/absence of pain
About the study
This is a pilot study evaluating the ability of the Temporo-masseteric Nerve Block local anesthetic injection (this was called the Twin Block earlier) to reduce pain experienced by individuals undergoing removal of lower third molar(s) under intravenous sedation. Study participants will be queried for pain experience and pain medications taken during the first post-operative week and will present for a follow-up visit on Day 8.
What is being tested
- Temporo-masseteric Nerve Block (drug)
Sponsor: Rutgers, The State University of New Jersey · Participants: 20 · Started: Sep 13, 2022
Contact the study team
- Gayathri Subramanian, PhD, DMD · Phone: 9739723418
- Samuel YP Quek, DMD, MPH · Phone: 732 570 1996
Official record on ClinicalTrials.gov — NCT05335070
Locations in the U.S.
| New Jersey | The University Hospital- Dental Clinic, Newark |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.