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Acute Pain clinical trials recruiting in the U.S.
30 studies for Acute Pain are recruiting participants at sites across the United States.
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Recently updated studies
Latinx Children and Surgery
RecruitingHealthy volunteers welcome
Ages 2 to 12 ยท All sexes ยท Updated Sep 24, 2026 ยท NCT06020677Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06471075Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
RecruitingPhase 4
Ages 18 to 120 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06364540Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Aug 19, 2026 ยท NCT06603662Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain
Recruiting
Ages 18 and older ยท All sexes ยท Updated Jul 13, 2026 ยท NCT07562412Vasopressin and Pain Perception in the Brain
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 65 ยท All sexes ยท Updated Jul 9, 2026 ยท NCT03446456Twin Block, Pain Medications and Third Molar Extractions
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jun 22, 2026 ยท NCT04880707Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated May 22, 2026 ยท NCT06466941TENS Analgesia During Outpatient Urethral Bulking for Stress Urinary Incontinence.
Recruiting
Ages 18 and older ยท Women ยท Updated May 13, 2026 ยท NCT06369922Variability in Analgesic Response to Ibuprofen
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated May 6, 2026 ยท NCT06539741A Study of LY4515100 in Participants With Pain Following Third Molar Removal
RecruitingPhase 2
Ages 18 to 40 ยท All sexes ยท Updated May 1, 2026 ยท NCT07511816Cold and Compression After Rotator Cuff Repair (RCR)
Recruiting
Ages 35 and older ยท All sexes ยท Updated Apr 14, 2026 ยท NCT07516327Studying Melatonin and Recovery in Teens
Recruiting
Ages 12 to 18 ยท All sexes ยท Updated Mar 18, 2026 ยท NCT06093477Phase 1 Study of SBS-147 in Healthy Adults
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 ยท All sexes ยท Updated Mar 3, 2026 ยท NCT07335913Virtual Reality and Standard Care vs. Standard Care Alone for Acute MSK Pain in Geriatric ED Patients
Recruiting
Ages 65 to 120 ยท All sexes ยท Updated Jan 16, 2026 ยท NCT06685107Characterization of Acute Pain
RecruitingObservational study
Ages 6 to 21 ยท All sexes ยท Updated Jan 14, 2026 ยท NCT07336264Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises
Recruiting
Ages 18 and older ยท All sexes ยท Updated Dec 24, 2025 ยท NCT06184126fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 35 ยท All sexes ยท Updated Dec 19, 2025 ยท NCT04439552Reducing Pain From Wisdom Molar Extractions
RecruitingPhase 2
Ages 18 to 64 ยท All sexes ยท Updated Dec 5, 2025 ยท NCT05335070Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Nov 26, 2025 ยท NCT04166877Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Recruiting
Ages 18 to 70 ยท All sexes ยท Updated Oct 20, 2025 ยท NCT05700279Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 19, 2025 ยท NCT05754190Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 19, 2025 ยท NCT05094297COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2025 ยท NCT06164028Empathy Through Pain Control: Lidocaine Paracervical Block for IUD Placements
RecruitingHealthy volunteers welcome
Ages 18 to 50 ยท Women ยท Updated Jun 13, 2025 ยท NCT06960317From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.