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Long-term COVID and Rehabilitation
Evaluating the Long-term Health Consequences of COVID-19 and Rehabilitation Therapies to Speed Convalescence
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Long-COVID and COVID-recovered patients must have SARS-CoV-19 positive test near the time of COVID-19 diagnosis * Long-COVID and COVID-recovered patients must be 3-12 months post-initial COVID-19 diagnosis * Ability to sign informed consent Exclusion Criteria: * BMI \>45 kg/m2 * Unstable (\<6 months) or severe coronary artery disease (CAD-RADS score = 4A), peripheral artery disease (Ankle Brachial Index \<0.40), cerebrovascular disease (identified by previous stroke in last 12 months), severe COPD (=Stage III), uncontrolled hypertension (\>160/100 mmHg), chronic kidney disease requiring dialysis, severe renal insufficiency (creatinine clearance \<30 by the Cockcroft-Gault formula), Alzheimer's disease, dementia * Orthopedic limitations that would prohibit exercise * Current smokers and individuals that stopped smoking in the last 10 years * Already taking Mito-Q or unwilling to cease dietary supplements for participation * Any other condition or event considered exclusionary by the PIs or a physician
About the study
The proposed focuses on improving both morbidity and mortality in older Veterans and those recovering from COVID-19 by developing rehabilitation therapies to augment vascular endothelial function by combating the oxidative stress and inflammation associated with aging and further induced by COVID-19. The investigators expected outcomes will have an important positive impact because they will provide scientifically sound recommendations for rehabilitation to improve vascular endothelial function and minimize the long-term consequences of COVID-19.
What is being tested
- Mitoquinone (dietary supplement)
- Placebo (dietary supplement)
Sponsor: VA Office of Research and Development · Participants: 300 · Started: Nov 1, 2022
Contact the study team
- Joel D Trinity, PhD · Phone: (801) 582-1565
- Russell S Richardson, PhD · Phone: (801) 582-1565
Official record on ClinicalTrials.gov — NCT05373043
Locations in the U.S.
| Utah | VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.