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Long COVID clinical trials recruiting in the U.S.
116 studies for Long COVID are recruiting participants at sites across the United States.
Anyone who has had COVID-19 can have long-lasting symptoms, know as long COVID. Learn about the symptoms and how to manage them, diagnosis, and prevention.
Cities with the most studies
- New York City, NY17 studies
- Houston, TX14 studies
- Chicago, IL12 studies
- Washington, DC12 studies
- Boston, MA11 studies
- Baltimore, MD11 studies
- Hialeah, FL8 studies
- Durham, NC8 studies
- San Francisco, CA8 studies
- Atlanta, GA7 studies
- San Diego, CA7 studies
- Miami, FL7 studies
- Pittsburgh, PA6 studies
- Los Angeles, CA6 studies
- Dallas, TX5 studies
- Salt Lake City, UT5 studies
- Seattle, WA5 studies
- Columbus, OH5 studies
- Louisville, KY5 studies
- San Antonio, TX4 studies
- Cincinnati, OH4 studies
- Mountain View, CA4 studies
- Nashville, TN4 studies
- Tampa, FL4 studies
- Charleston, SC3 studies
- Homestead, FL3 studies
- The Woodlands, TX3 studies
- Philadelphia, PA3 studies
- Cleveland, OH3 studies
- Sacramento, CA3 studies
- Detroit, MI3 studies
- Aurora, CO3 studies
- Boise, ID3 studies
- Omaha, NE3 studies
- Portland, OR3 studies
- Austin, TX3 studies
- New Orleans, LA3 studies
- St. Petersburg, FL3 studies
- Richmond, VA3 studies
- St. Louis, MO3 studies
By state
- Alabama5 studies
- Arizona4 studies
- California32 studies
- Colorado7 studies
- District of Columbia4 studies
- Florida14 studies
- Georgia10 studies
- Idaho3 studies
- Illinois14 studies
- Kentucky7 studies
- Louisiana6 studies
- Maryland22 studies
- Massachusetts11 studies
- Michigan7 studies
- Minnesota6 studies
- Missouri3 studies
- Nebraska3 studies
- Nevada4 studies
- New Jersey3 studies
- New York20 studies
- North Carolina11 studies
- Ohio12 studies
- Oregon3 studies
- Pennsylvania11 studies
- South Carolina4 studies
- Tennessee8 studies
- Texas24 studies
- Utah7 studies
- Virginia6 studies
- Washington6 studies
Recently updated studies
Exploring the Extended Efficacy and Initial Use of RUCONEST® in Managing Neurological Symptoms Linked to Infectious Pathogens
RecruitingPhase 4
Ages 18 to 90 · All sexes · Updated Nov 12, 2026 · NCT07932002Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence
RecruitingObservational studyHealthy volunteers welcome
1 Day – 99 Years · All sexes · Updated Nov 12, 2026 · NCT04582903Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05796505Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT03963622The Effect of COVID-19 Pandemic on Adolescent and Young Adult Cancer Patients and Survivors
RecruitingObservational study
Ages 18 to 39 · All sexes · Updated Nov 10, 2026 · NCT04551378A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1283 in Participants ≥6 Months to <12 Years of Age
RecruitingPhase 2Healthy volunteers welcome
6 Months – 11 Years · All sexes · Updated Nov 9, 2026 · NCT07808697Home-Based Exercise Tele-Rehabilitation After COVID-19
RecruitingHealthy volunteers welcome
Ages 50 to 85 · All sexes · Updated Nov 6, 2026 · NCT05425264A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06667700Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
RecruitingPhase 3
28 Days · All sexes · Updated Nov 4, 2026 · NCT02735707A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Formulations
RecruitingPhase 4Healthy volunteers welcome
Ages 12 and older · All sexes · Updated Nov 4, 2026 · NCT07863635Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Nov 3, 2026 · NCT04573062A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe Disease
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 3, 2026 · NCT07743580Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study
RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 79 · All sexes · Updated Nov 2, 2026 · NCT07287137Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06160128Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT05624450Viral Infections in Healthy and Immunocompromised Hosts
RecruitingObservational studyHealthy volunteers welcome
6 Months – 120 Years · All sexes · Updated Oct 29, 2026 · NCT01306084SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 28, 2026 · NCT07597902Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · Women · Updated Oct 23, 2026 · NCT04983251Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
Recruiting
Ages 11 to 18 · All sexes · Updated Oct 21, 2026 · NCT04978571Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Oct 16, 2026 · NCT07093580LIFT: Life Improvement Trial
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 15, 2026 · NCT06366724A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Oct 15, 2026 · NCT06679140A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT07013474Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Oct 9, 2026 · NCT07149428Impact of COVID-19 Pandemic on Out-of-Pocket Costs, Lost Wages, and Unemployment in Patients With Breast Cancer Undergoing Breast Surgery
RecruitingObservational study
Ages 18 and older · Women · Updated Oct 7, 2026 · NCT04169542From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.