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Long COVID clinical trials recruiting in the U.S.

116 studies for Long COVID are recruiting participants at sites across the United States.

Anyone who has had COVID-19 can have long-lasting symptoms, know as long COVID. Learn about the symptoms and how to manage them, diagnosis, and prevention.

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Recently updated studies

Exploring the Extended Efficacy and Initial Use of RUCONEST® in Managing Neurological Symptoms Linked to Infectious Pathogens

RecruitingPhase 4
Ages 18 to 90 · All sexes · Updated Nov 12, 2026 · NCT07932002

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence

RecruitingObservational studyHealthy volunteers welcome
1 Day – 99 Years · All sexes · Updated Nov 12, 2026 · NCT04582903

Addressing Vaccine Acceptance in Carceral Settings Through Community Engagement

Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05796505

Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)

Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT03963622

The Effect of COVID-19 Pandemic on Adolescent and Young Adult Cancer Patients and Survivors

RecruitingObservational study
Ages 18 to 39 · All sexes · Updated Nov 10, 2026 · NCT04551378

A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1283 in Participants ≥6 Months to <12 Years of Age

RecruitingPhase 2Healthy volunteers welcome
6 Months – 11 Years · All sexes · Updated Nov 9, 2026 · NCT07808697

Home-Based Exercise Tele-Rehabilitation After COVID-19

RecruitingHealthy volunteers welcome
Ages 50 to 85 · All sexes · Updated Nov 6, 2026 · NCT05425264

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingPhase 3
28 Days · All sexes · Updated Nov 4, 2026 · NCT02735707

A Study to Investigate the Immunogenicity and Safety of mRNA COVID-19 Variant-containing Formulations

RecruitingPhase 4Healthy volunteers welcome
Ages 12 and older · All sexes · Updated Nov 4, 2026 · NCT07863635

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Nov 3, 2026 · NCT04573062

A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe Disease

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Nov 3, 2026 · NCT07743580

Comparative Immunogenicity of Respiratory Virus Vaccines (CIRV2) Study

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 79 · All sexes · Updated Nov 2, 2026 · NCT07287137

Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT06160128

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT05624450

Viral Infections in Healthy and Immunocompromised Hosts

RecruitingObservational studyHealthy volunteers welcome
6 Months – 120 Years · All sexes · Updated Oct 29, 2026 · NCT01306084

SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 28, 2026 · NCT07597902

Women s Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · Women · Updated Oct 23, 2026 · NCT04983251

Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)

Recruiting
Ages 11 to 18 · All sexes · Updated Oct 21, 2026 · NCT04978571

Study of S-892216 Long-acting Injectable (LAI) in Healthy Adult Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Oct 16, 2026 · NCT07093580

LIFT: Life Improvement Trial

RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 15, 2026 · NCT06366724

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 14, 2026 · NCT07013474

Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Oct 9, 2026 · NCT07149428

Impact of COVID-19 Pandemic on Out-of-Pocket Costs, Lost Wages, and Unemployment in Patients With Breast Cancer Undergoing Breast Surgery

RecruitingObservational study
Ages 18 and older · Women · Updated Oct 7, 2026 · NCT04169542

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.