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Neural Connectivity During Therapy for Adolescent PTSD
Neural Connectivity Before and After Each of the Three Treatment Phases of Trauma-focused Therapy for Adolescent Posttraumatic Stress
Who can join
Ages 12 to 17 · All sexes
Full eligibility criteria
Inclusion Criteria: * ages 12-17 and Tanner stage 2 or above * history of interpersonal trauma * PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month Exclusion Criteria: * current or past use of psychiatric medications * severe suicidal/homicidal ideation * current hospitalization * other current psychotherapy or previous treatment with TF-CBT * history of head injury with loss of consciousness for \>5 minutes * IQ\<85 * major medical illness * MRI contraindications (metal in body; braces on teeth) * psychosis, bipolar 1, autism, developmental disorder, panic disorder * first-degree family member with diagnosis of psychosis or bipolar I disorder * substance dependence within the past 3 months or current drug use that is frequent
About the study
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.
What is being tested
- TF-CBT (behavioral)
- TAU (behavioral)
Sponsor: The University of Texas Health Science Center at San Antonio · Participants: 180 · Started: Nov 29, 2022
Contact the study team
- Amy Garrett, PhD · Phone: 12105678189
- Natalia Gomez-Giulilani · Phone: 2105678016
Official record on ClinicalTrials.gov — NCT05423444
Locations in the U.S.
| Texas | UT Health Department of Psychiatry, San Antonio |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.