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Depression and Driving

The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older Adults (Depression and Driving)

Who can join

Ages 65 and older · All sexes

Inclusion Criteria:

* Drive on average at least once per week
* Has a valid driver's license
* Willing to complete blood draw
* Willing to complete either lumbar puncture or PET imaging
* 65 years or older
* Speaks English

Exclusion Criteria:

* Not willing to complete blood draw and/or one other biomarker
* Less than 65 years of age
* Does not drive a vehicle/ is no longer actively driving

About the study

This project will assess how depression, preclinical AD, and antidepressants affect driving behavior in cognitively normal older adults (65 years).

What is being tested

• F 18 AV-1451 (Flortaucipir) (drug)
• [11C]-Pittsburgh Compound B ([11C]PiB) (drug)

Sponsor: Washington University School of Medicine · Participants: 150 · Started: Jun 17, 2021

Contact the study team

• Kaylin Taylor, MA · Phone: 314-273-3573
• Beau Ances, MD, PhD · Phone: (314) 747-8423

Official record on ClinicalTrials.gov — NCT05446805

Locations in the U.S.

Conditions

• Depression

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.