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Factors in Learning And Plasticity: Macular Degeneration
Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss: Macular Degeneration
Who can join
Ages 18 to 89 · All sexes
Full eligibility criteria
Inclusion Criteria: * Aged 18-89 * Severely impaired vision in both eyes (20/100 or worse) * diagnosis of Macular Degeneration by an Ophthalmologist * Light sensitivity in the macular retina that is at least 10 dB units worse than in peripheral regions, as demonstrated by a scanning laser ophthalmoscope (MAIA) * Medical record review indicating this level of disease severity has been present for at least 2 years * Reside within 50 miles of study site Exclusion Criteria: * Pacemaker or any ferromagnetic metal implanted in their body * Metal of any type implanted in their head (limited dental work is acceptable) * Claustrophobia * Being hearing-impaired * Weight over 300 pounds * Maximum body girth over 60 inches * Previous serious head injury * Presence of hallucinations or delusions * Excessive old, or colorful tattoos, especially near the head * Pregnancy * Braces/permanent retainer
About the study
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging population are consistent with the mission of the NIA.
What is being tested
- Training visual sensitivity (behavioral)
- Combination training (behavioral)
Sponsor: University of Alabama at Birmingham · Participants: 60 · Started: Nov 1, 2022
Contact the study team
- Rachel A Chua, MS · Phone: 205-410-4041
- Kristina M Visscher, PhD · Phone: 205-934-0497
Official record on ClinicalTrials.gov — NCT05454124
Locations in the U.S.
| Alabama | UAB, Birmingham |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.