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Multiomic Diagnostics in Youth With Psychosis

Multiomic Diagnostics in Child and Adolescent Psychosis

Who can join

Ages 7 to 17 · All sexes

Inclusion Criteria:

Individual in whom one of the following criteria is met:

1. Child/adolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis

   OR
2. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.

Exclusion Criteria:

Child/Adolescent patients who do not meet any of the inclusion criteria, or those who:

1. Already received any prior whole genome sequencing or exome sequencing.
2. Unable to approach the family or patient for enrollment.
3. Unable to obtain informed consent.
4. Family members are ineligible for participation in this study if:

   1. They are known to not be genetically related to the child/adolescent patient participant
   2. They are a member of a protected research population

About the study

Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of psychosis that may inform new treatment for future patients.

What is being tested

• Genetic: Genomic sequencing and molecular diagnostic results, if any. (genetic)
• Phage display ImmunoPrecipiation Sequencing (PhIP-Seq) (diagnostic test)

Sponsor: Rady Pediatric Genomics & Systems Medicine Institute · Participants: 15 · Started: Oct 10, 2022

Contact the study team

• Aaron Besterman, MD · Phone: 858-576-1700
• Corrine Blucher, BS · Phone: 858-576-1700

Official record on ClinicalTrials.gov — NCT05457140

Locations in the U.S.

Conditions

• Psychotic Disorders

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.