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Psychotic Disorders clinical trials recruiting in the U.S.

75 studies for Psychotic Disorders are recruiting participants at sites across the United States.

Psychotic disorders are severe mental disorders that cause abnormal thinking and perceptions. Two main symptoms are delusions and hallucinations. Learn more.

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Recently updated studies

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

RecruitingPhase 2
Ages 55 to 90 · All sexes · Updated Nov 12, 2026 · NCT06887192

FAmily Engagement Strategy for Coordinated Specialty Care

Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06945055

Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium (CNTRACS): Study 1

RecruitingHealthy volunteers welcome
Ages 18 to 59 · All sexes · Updated Nov 9, 2026 · NCT07853807

Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3

RecruitingHealthy volunteers welcome
Ages 18 to 59 · All sexes · Updated Nov 9, 2026 · NCT07900893

REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)

Recruiting
Ages 18 to 50 · All sexes · Updated Nov 4, 2026 · NCT07006935

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

RecruitingPhase 2
Ages 55 and older · All sexes · Updated Nov 3, 2026 · NCT06540833

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

RecruitingPhase 3
Ages 55 to 90 · All sexes · Updated Oct 27, 2026 · NCT06585787

Developing a Recovery-Oriented Suicide Prevention Program for Young People at Clinical High Risk for Psychosis

Recruiting
Ages 12 to 30 · All sexes · Updated Oct 22, 2026 · NCT07756567

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 15, 2026 · NCT07459647

Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis

Recruiting
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT05440214

iTBS to Enhance Social Cognition in People With Psychosis

Recruiting
Ages 18 to 39 · All sexes · Updated Oct 8, 2026 · NCT06118268

Volatility in Paranoia (VIP) Trial: An RCT of Changes in Volatility With Psychotherapy

Recruiting
Ages 18 to 65 · All sexes · Updated Sep 30, 2026 · NCT06835556

State Representation in Early Psychosis 2

RecruitingObservational studyHealthy volunteers welcome
Ages 15 to 45 · All sexes · Updated Sep 22, 2026 · NCT07834203

Cerebellar Modulation of Cognition in Psychosis

Recruiting
Ages 18 to 55 · All sexes · Updated Aug 20, 2026 · NCT06107764

Enhancing Veteran-Clinical Collaboration in VA PRRCs

Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

Recruiting
Ages 18 to 45 · All sexes · Updated Aug 17, 2026 · NCT06221852

Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

Recruiting
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07359157

Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

RecruitingPhase 1
Ages 10 to 17 · All sexes · Updated Aug 11, 2026 · NCT05025605

BRAVE Program to Improve Safety and Reduce Violence Risk in Early Psychosis

Recruiting
Ages 16 to 30 · All sexes · Updated Jul 29, 2026 · NCT07417904

Determining the Role of Social Reward Learning in Social Anhedonia

Recruiting
Ages 18 to 35 · All sexes · Updated Jul 27, 2026 · NCT05617898

Cognitive Strategies in Early Psychosis 2

RecruitingPhase 3
Ages 18 to 35 · All sexes · Updated Jul 23, 2026 · NCT07263022

Transition Care for FEP

RecruitingObservational study
Ages 18 to 40 · All sexes · Updated Jul 20, 2026 · NCT07713849

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

RecruitingHealthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Jul 16, 2026 · NCT04940663

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.