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Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI

Recruiting

Targeted Spinal Cord Plasticity for Alleviating SCI-related Neuropathic Pain

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

1. neurologically stable (\>1 year post SCI)
2. medical clearance to participate
3. ability to stand with or without an assistive device for at least 3 minutes at a time
4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)
5. For participants with neuropathic pain, the area of neuropathic pain must include lower leg.

Exclusion Criteria:

1. motoneuron injury
2. known cardiac condition
3. medically unstable condition (incl. pregnancy)
4. cognitive impairment
5. uncontrolled peripheral neuropathy
6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment
7. daily use of electrical stimulation to the leg
8. complete lack of cutaneous sensation around foot.

About the study

The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

What is being tested

Sponsor: Medical University of South Carolina · Participants: 15 · Started: Mar 27, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05492188

Locations in the U.S.

South CarolinaMedical University of South Carolina, Charleston

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.