Home › Tumors and Pregnancy › NCT05492708
The Heartland Study
Children's Health in the Heartland Study
Who can join
Ages 18 and older · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Pregnant persons ages 18 or older at time of consent who are ≤20+6 weeks pregnant. Best clinical estimate of gestational age will be utilized for recruitment purposes. Enrollment in the first trimester (≤ 13 + 6) is preferred, but anyone ≤ 20 +6 is permitted. * Living in one of the 13 Heartland Study region states at the time of enrollment (Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin) Optional inclusion of the putative biological father Exclusion Criteria: * Participants who are not fluent in and/or do not fully understand, read, write, or speak the English language. * Other inability to provide informed consent to participate
About the study
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..
The objective of the Heartland Study is to address major knowledge gaps concerning the health effects of herbicides on maternal and infant health. The study is being conducted to evaluate the associations between environmental exposures to herbicides during and after pregnancy and reproductive health outcomes. The study is measuring multiple biomarkers of herbicide exposure among pregnant Midwesterners and their partners to evaluate associations with pregnancy and childbirth outcomes, epigenetic biomarkers of exposure, and child development.
Sponsor: Heartland Health Research Alliance · Participants: 2,600 · Started: Jan 11, 2020
Contact the study team
- Kathleen Flannery · Phone: 317-880-3961
Official record on ClinicalTrials.gov — NCT05492708
Locations in the U.S.
| Indiana | Indiana University Medical Center, Indianapolis |
| Iowa | University of Iowa Health Care, Iowa City |
| Wisconsin | Marshfield Clinic, Marshfield |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.