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Benefits of Nicotinamide Riboside Upon Cognition and Sleep
The Benefits of Nicotinamide Riboside Upon Cognition and Sleep in Older Veterans
Who can join
Ages 65 to 85 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5 Exclusion Criteria: * Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20
About the study
Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.
What is being tested
- Nicotinamide riboside (dietary supplement)
- Placebo (dietary supplement)
Sponsor: State University of New York at Buffalo · Participants: 50 · Started: Apr 4, 2023
Contact the study team
- Carleara Weiss, PhD, MS, RN · Phone: 7168282006
- Rebecca A Lorenz, PhD, RN · Phone: 716-829-2204
Official record on ClinicalTrials.gov — NCT05500170
Locations in the U.S.
| New York | Buffalo Veteran Affairs Medical Center, Buffalo State University of New York at Buffalo, Buffalo (Not yet recruiting) University at Buffalo State University of New York, Buffalo (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.