Home › Post-Traumatic Stress Disorder › NCT05517304
Transcutaneous Vagal Nerve Stimulation in Veterans With Posttraumatic Stress Disorder
Recruiting
Who can join
Ages 18 to 75 · All sexes
Full eligibility criteria
Inclusion Criteria: * Veterans between the ages of 18 and 75 will be included with a diagnosis of PTSD based on DSM-5 criteria Exclusion Criteria: Subjects will be excluded with: * a history of mild traumatic brain injury (mTBI) based on VA Criteria * moderate or greater TBI * positive pregnancy test * meningitis or other neurological disorder * alcohol or substance abuse use disorder based on DSM-5 criteria within the past 12 months * current or lifetime history of schizophrenia, schizoaffective disorder, bipolar I disorder, anorexia nervosa or bulimia, based on DSM-5 * active suicidal ideation with a plan * a history of serious medical or neurological illness, such as cardiovascular, gastrointestinal, hepatic, renal, neurologic or other systemic illness that would preclude participation based on clinical judgment of the PI * active opiate or benzodiazepine treatment * history of structural abnormality on brain MRI or CT if one has been performed in the past
About the study
This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts before and after three months of twice daily treatment with tcVNS or sham stimulation at home.
What is being tested
- tcVNS (device)
- Sham (device)
Sponsor: VA Office of Research and Development · Participants: 80 · Started: Oct 1, 2022
Contact the study team
- Doug J Bremner, MD · Phone: (404) 712-9569
Official record on ClinicalTrials.gov — NCT05517304
Locations in the U.S.
| Georgia | Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.