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Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

Pre-Operative ERAS® (Enhanced Recovery After Surgery): Randomized Feasibility Trial of Implementing Individualized Prehabilitation for People Undergoing Neo-Adjuvant Radiotherapy and Lower Limb Soft-Tissue Sarcoma Surgery

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Histologically or cytologically-proven deep soft tissue sarcoma (STS) of the lower extremity
* Localized
* Adults, 18 and older
* All gender types
* Subjects must be able to provide appropriate consent or have an appropriate representative available to do so

Exclusion Criteria:

* Soft tissue sarcomas that are in a superficial location relative to fascia
* Patients with metastatic disease (distant or nodal)
* Both and upper and lower extremity involvement

About the study

This clinical trial evaluates whether patients with deep soft tissue sarcomas who receive a tailored prehabilitation exercise regimen during standard radiotherapy and prior to standard of care surgery have better recovery and surgical outcomes than those who do not. Patients undergoing surgery to soft tissue sarcomas are at high risk for post-operative disability, which is associated with high rates of depression and poor health-related quality of life. Prehabilitation is the practice of exercising before surgery to ensure that the patient is in the best possible condition. It allows patients to prepare their bodies for recovery after surgery, which may result in better surgical outcomes, recovery, and quality of life after surgery.

What is being tested

• Computed Tomography (procedure)
• Educational Intervention (other)
• Magnetic Resonance Imaging (procedure)
• Physical Therapy (procedure)
• Questionnaire Administration (other)
• Telemedicine (other)

Sponsor: Mayo Clinic · Participants: 33 · Started: Jun 8, 2022

Contact the study team

• Clinical Trials Referral Office · Phone: 855-776-0015

Official record on ClinicalTrials.gov — NCT05526417

Locations in the U.S.

Conditions

• Soft Tissue Sarcoma

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.