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Soft Tissue Sarcoma clinical trials recruiting in the U.S.
136 studies for Soft Tissue Sarcoma are recruiting participants at sites across the United States.
Soft tissue sarcoma refers to cancer that begins in the muscle, fat, vessels or tendons. It can cause a lump or swelling. See which treatments are available
Cities with the most studies
- Houston, TX32 studies
- New York City, NY20 studies
- Boston, MA17 studies
- Los Angeles, CA13 studies
- St. Louis, MO12 studies
- Columbus, OH12 studies
- Washington, DC11 studies
- Memphis, TN10 studies
- Philadelphia, PA9 studies
- Aurora, CO8 studies
- Nashville, TN8 studies
- Durham, NC8 studies
- Queens, NY8 studies
- Rochester, MN7 studies
- Dallas, TX7 studies
- Atlanta, GA7 studies
- Chicago, IL7 studies
- Grand Rapids, MI7 studies
- Baldwin Park, CA7 studies
- Greenburgh, NY7 studies
- Santa Monica, CA7 studies
- Mountain View, CA6 studies
- Miami, FL6 studies
- Orange, CA6 studies
- Staten Island, NY6 studies
- New Rochelle, NY6 studies
- Edison, NJ6 studies
- East Norwalk, CT6 studies
- Arlington, VA5 studies
- Baltimore, MD5 studies
- Cleveland, OH5 studies
- San Francisco, CA5 studies
- Birmingham, AL5 studies
- Pittsburgh, PA5 studies
- Cincinnati, OH4 studies
- Jacksonville, FL4 studies
- Omaha, NE4 studies
- Charlotte, NC3 studies
- Tampa, FL3 studies
- The Bronx, NY3 studies
By state
- Alabama6 studies
- Arizona5 studies
- California39 studies
- Colorado11 studies
- Connecticut4 studies
- District of Columbia6 studies
- Florida20 studies
- Georgia8 studies
- Illinois9 studies
- Iowa3 studies
- Kansas3 studies
- Maryland10 studies
- Massachusetts18 studies
- Michigan9 studies
- Minnesota10 studies
- Missouri13 studies
- Nebraska4 studies
- New Jersey8 studies
- New York27 studies
- North Carolina13 studies
- Ohio21 studies
- Oregon3 studies
- Pennsylvania15 studies
- Tennessee18 studies
- Texas36 studies
- Utah6 studies
- Virginia7 studies
- Wisconsin4 studies
Recently updated studies
SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07049848Safety and Feasibility of Intraoperative Visualization With Cytalux in Children
RecruitingPhase 1
Ages 6 to 17 · All sexes · Updated Nov 12, 2026 · NCT06235125Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Nov 12, 2026 · NCT06444880BostonGene and Exigent Genomic INsight Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06272864Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma
RecruitingPhase 1/2
Ages 2 to 30 · All sexes · Updated Nov 5, 2026 · NCT05734066Anti-GD2 ADC M3554 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06641908cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic Sarcoma
RecruitingPhase 2
Ages 8 to 30 · All sexes · Updated Nov 4, 2026 · NCT05726383Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT05711615Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06760819T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.
RecruitingPhase 1
Ages 12 and older · All sexes · Updated Nov 3, 2026 · NCT06474676Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
RecruitingPhase 1
Ages 3 to 35 · All sexes · Updated Nov 3, 2026 · NCT02390752Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients
RecruitingEarly phase 1
Ages 12 to 17 · All sexes · Updated Nov 2, 2026 · NCT07658768Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma Patients
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07227961Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT0728373118F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Oct 29, 2026 · NCT06503146Lead-212 PSV359 Therapy for Patients With Solid Tumors
RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Oct 28, 2026 · NCT06710756A Study of MGC026 in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06242470A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06942442STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT06975293A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07705334Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT06498648LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy and Spectroscopy-based Molecular Urinalysis in Sarcoma Patients
RecruitingObservational study
All ages · All sexes · Updated Oct 21, 2026 · NCT06958107PROACT AYA: Preventing Overweight/Obesity-Associated Cardiotoxicity With Tirzepatide In Adolescent And Young Adult Cancer Survivors - A Phase 2 Single-Arm, Single-Center Feasibility Study
RecruitingPhase 2
Ages 18 to 39 · All sexes · Updated Oct 20, 2026 · NCT07874828From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.