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Soft Tissue Sarcoma clinical trials recruiting in the U.S.

136 studies for Soft Tissue Sarcoma are recruiting participants at sites across the United States.

Soft tissue sarcoma refers to cancer that begins in the muscle, fat, vessels or tendons. It can cause a lump or swelling. See which treatments are available

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Recently updated studies

Safety and Feasibility of Intraoperative Visualization With Cytalux in Children

RecruitingPhase 1
Ages 6 to 17 · All sexes · Updated Nov 12, 2026 · NCT06235125

Phase II Trial of Ubamatamab Alone or in Combination With Cemiplimab in MUC16-Expressing SMARCB1-Deficient Malignancies

RecruitingPhase 2
Ages 12 and older · All sexes · Updated Nov 12, 2026 · NCT06444880

BostonGene and Exigent Genomic INsight Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06272864

Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

RecruitingPhase 1/2
Ages 2 to 30 · All sexes · Updated Nov 5, 2026 · NCT05734066

Anti-GD2 ADC M3554 in Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06641908

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT05366881

Iscador® P (Mistletoe) Immunotherapy for Recurrent Resectable Osteogenic Sarcoma

RecruitingPhase 2
Ages 8 to 30 · All sexes · Updated Nov 4, 2026 · NCT05726383

Distance-Based Exercise to Preserve Function and Prevent Disability

Recruiting
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07059884

Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients

RecruitingEarly phase 1
Ages 12 to 17 · All sexes · Updated Nov 2, 2026 · NCT07658768

Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma Patients

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07227961

Phase 2 Trial of Zanzalintinib and Pembrolizumab in Select Subtypes of Advanced/Metastatic Soft-tissue Sarcoma

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07283731

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Oct 29, 2026 · NCT06503146

Lead-212 PSV359 Therapy for Patients With Solid Tumors

RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Oct 28, 2026 · NCT06710756

A Study of MGC026 in Participants With Advanced Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06242470

A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06942442

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 22, 2026 · NCT07705334

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT06498648

LCI-SAR-BSTS-CTDNA-001: Circulating Tumor DNA Liquid Biopsy and Spectroscopy-based Molecular Urinalysis in Sarcoma Patients

RecruitingObservational study
All ages · All sexes · Updated Oct 21, 2026 · NCT06958107

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.