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Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Safest Choice of Antihypertensive Regimen for Postpartum Hypertension: A Randomized Control Trial (SCARPH)

Who can join

Ages 18 and older · Women

Inclusion Criteria:

* Female
* Women who develop postpartum hypertension\* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.

  * Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.

Exclusion Criteria:

* History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
* Contraindication to either Nifedipine or Labetalol
* HR \<60 or \>110
* Native language other than English or Spanish

About the study

The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.

What is being tested

• Oral Nifedipine (drug)
• Oral Labetalol (drug)

Sponsor: Loma Linda University · Participants: 500 · Started: May 8, 2023

Contact the study team

• Ashra Denise B Tugung, BSc · Phone: 9096515580
• Nikia Gray-Hutto, RN, CCRP · Phone: 9095584000

Official record on ClinicalTrials.gov — NCT05551104

Locations in the U.S.

Conditions

• High Blood Pressure in Pregnancy
• High Blood Pressure

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.