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Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Who can join

Ages 18 to 89 · All sexes

Inclusion Criteria:

1. Male or Female, age 18-89
2. Chronic pain for more than 3 months
3. Willing to visit a research lab
4. Willing to undergo a blood draw
5. Able to provide written informed consent

Exclusion Criteria

1. History of neurological disease (e.g., dementias, Parkinson's)
2. History of stroke
3. Current diagnosis of cancer
4. Subject is unwilling or unable to comply with the protocol

About the study

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

What is being tested

• Permanent Epidural Spinal Cord Stimulation (device)

Sponsor: University of Alabama at Birmingham · Participants: 80 · Started: Aug 2, 2022

Contact the study team

• Chris Gonzalez, MS · Phone: (205) 975-3732

Official record on ClinicalTrials.gov — NCT05556902

Locations in the U.S.

Conditions

• Low Back Pain
• High Blood Pressure

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.