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Physiology of Long COVID-19 and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity
Physiological Underpinnings of Post-Acute Sequelae of SARS CoV-2 ("Long COVID") and Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Adults ≥18 years with documented history of COVID-19 infection and symptoms consistent with Long COVID lasting \>12 weeks after diagnosis. Exclusion Criteria: * History of cardiovascular/pulmonary disease prior to infection * COVID-related myocardial injury such as evidence of myocarditis * Deep vein thrombosis/pulmonary embolism following COVID-19 infection * Exercise intolerance resulting from conditions that are not related to cardiorespiratory or autonomic factors (e.g. osteoarthritis or other musculoskeletal diseases); * Dependency of supplemental oxygen following COVID infection due to cardiovascular and/or pulmonary complications following acute COVID infection
About the study
The primary objectives of this study are to determine whether exercise training is an effective strategy for treatment of Long COVID and characterize the cardiorespiratory and autonomic physiology in these patients to precisely characterize mechanisms contributing to this syndrome.
What is being tested
- Exercise (behavioral)
Sponsor: University of Colorado, Denver · Participants: 30 · Started: Mar 1, 2023
Contact the study team
- William K Cornwell, III, MD · Phone: 303-724-2085
Official record on ClinicalTrials.gov — NCT05566483
Locations in the U.S.
| Colorado | University of Colorado Hospital, Aurora |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.