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Lifestyle Interventions for the Treatment of Early Onset Alzheimer's Disease Study

Who can join

Ages 40 to 75 · All sexes

Inclusion Criteria:

* Enrolled in the Longitudinal Early-Onset AD Study (LEADS) parent study, and being classified via LEADS consensus criteria as having amyloid-positive Early Onset Alzheimer's Disease
* Aged 40-64 years at the time of enrollment into LEADS
* Fluent in English
* In good general health and absent another neurological disorder
* Have a knowledgeable informant.
* Have had a Clinical Dementia Rating scale of 0.5 to 1.0 at the time of enrollment into LEADS
* Have sufficient vision, hearing, comprehension, and manual dexterity to participate in the testing and training program

Exclusion Criteria:

• Have access to the internet (e.g., home, family, public library, etc.) for less than 4 hours per week

About the study

The purpose of this study is to generate preliminary data on the benefit of computerized cognitive training and Tai Chi- Qi Gong training in participants with Early-Onset Alzheimer's Disease. It is hypothesized that participants in the experimental training condition will perform better on outcomes related to cognition, functioning, and mood at follow-up compared to participants assigned to the active control condition.

What is being tested

• Cognitive Training (device)
• Tai Chi- Qi Gong (behavioral)
• Brain Games (device)
• Stretching (behavioral)

Sponsor: Indiana University · Participants: 60 · Started: Jan 11, 2024

Contact the study team

• Dustin B Hammers, PhD · Phone: 3179638557

Official record on ClinicalTrials.gov — NCT05573490

Locations in the U.S.

Conditions

• Alzheimer's Disease

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.