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Alzheimer's Disease clinical trials recruiting in the U.S.

243 studies for Alzheimer's Disease are recruiting participants at sites across the United States.

Alzheimer's disease is a brain disorder that slowly destroys memory and thinking skills. It's the most common cause of dementia among older adults.

Cities with the most studies

By state

Recently updated studies

PET Imaging in the Baltimore Longitudinal Study of Aging (BLSA)

RecruitingObservational studyHealthy volunteers welcome
Ages 55 to 110 · All sexes · Updated Nov 13, 2026 · NCT07099053

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

RecruitingHealthy volunteers welcome
Ages 18 to 89 · All sexes · Updated Nov 13, 2026 · NCT04800588

Neuroplasticity Enhancement From Cognitive Training Reinforced by Psilocybin

RecruitingPhase 2Healthy volunteers welcome
Ages 65 to 120 · All sexes · Updated Nov 13, 2026 · NCT07721467

Adaptango Performance PRocess for Older Adults Community reHabilitation

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07824128

A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

RecruitingPhase 2
Ages 55 to 90 · All sexes · Updated Nov 12, 2026 · NCT06887192

A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05231785

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

RecruitingPhase 3
Ages 55 to 90 · All sexes · Updated Nov 12, 2026 · NCT06937229

Make Better Choices 2 for Rural Appalachians

RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 10, 2026 · NCT04309461

Tennessee Alzheimer's Project

RecruitingObservational studyHealthy volunteers welcome
Ages 60 and older · All sexes · Updated Nov 10, 2026 · NCT05372172

Testing the Effects of a Text Message Caregiver Support Intervention for Latinos

RecruitingHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 9, 2026 · NCT06728436

CMN LIFU for Enhanced Amyloid Reduction (CLEART Study)

Recruiting
Ages 65 and older · All sexes · Updated Nov 9, 2026 · NCT07866768

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

RecruitingHealthy volunteers welcome
Ages 60 to 100 · All sexes · Updated Nov 6, 2026 · NCT06930560

A Study to Investigate the Safety and Effectiveness of SAR448851 in Participants With Early Alzheimer's Disease

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Nov 6, 2026 · NCT07688213

A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease

RecruitingPhase 3
Ages 55 to 80 · All sexes · Updated Nov 6, 2026 · NCT07717411

Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease

RecruitingPhase 1/2
Ages 50 to 86 · All sexes · Updated Nov 6, 2026 · NCT07651319

Study to Test Effects and Safety of RO7568282 in Early Symptomatic Alzheimer's Disease

RecruitingPhase 2
Ages 50 to 90 · All sexes · Updated Nov 6, 2026 · NCT07781657

Flutemetamol F 18 Injection Formulation Comparison

RecruitingPhase 2
Ages 50 to 110 · All sexes · Updated Nov 5, 2026 · NCT07873463

A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Nov 5, 2026 · NCT07787169

A Study of LY3439539 in Participants With Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Nov 4, 2026 · NCT07598370

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Nov 4, 2026 · NCT07589595

A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Psychosis Associated With Alzheimer's Disease

RecruitingPhase 2
Ages 55 and older · All sexes · Updated Nov 3, 2026 · NCT06540833

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.