Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

Inclusion Criteria - Stratum A: Sickle cell patients with diastolic dysfunction

* 18 to 21 years of age
* Black
* Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
* Three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)

Inclusion Criteria - Stratum B: Sickle cell patients without diastolic dysfunction

* 18 to 21 years of age
* Black
* Diagnosis of SCD of HbSS and HbSβ0thalassemia genotypes
* Two or less abnormal diastolic parameters

Inclusion Criteria - Stratum C: Healthy controls

* 18 to 21 years of age
* Black
* Two or less abnormal diastolic parameters

Exclusion Criteria - Stratum A:

* Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome in last 4 weeks
* Blood transfusion in the last 3 months
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast-feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.

Exclusion Criteria - Stratum B:

* Diagnosed with three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
* Recent hospitalization for vaso-occlusive pain crisis or acute chest syndrome in last 4 weeks
* Blood transfusion in the last 3 months
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high-grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast-feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.

Exclusion Criteria - Stratum C:

* All genotypes of SCD
* Diagnosed with three or more abnormal diastolic parameters (based on guidelines by American Society of echocardiography)
* Anemia of grade 2 or worse (per CTCAE v5.0) at study visit 1
* Individuals with signs, symptoms or EKG findings of acute myocardial ischemia, infarction or unstable angina
* Individuals with history of VT/VF or SVT
* Previous cardiac surgery
* Known congenital heart disease (other than patent ductus arteriosus or Atrial septal defect)
* Stenotic valvular disease or left main coronary artery stenosis
* History of myo/pericarditis
* Left ventricle systolic dysfunction
* Cardiovascular instability/uncontrolled hypertension (h/o hypertensive urgency or emergency)
* History of sinus node dysfunction or high-grade AV nodal block
* History of aborted sudden cardiac death or cardiac arrest
* Current seizure disorder on AED
* Pregnant/Breast- feeding
* Any medical or social reason, which, in the opinion of the principal investigators would make the participation of the subject ill-advised.