🔎 Trials Near Me

Home › Sickle Cell Disease

Sickle Cell Disease clinical trials recruiting in the U.S.

106 studies for Sickle Cell Disease are recruiting participants at sites across the United States.

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

Cities with the most studies

By state

Recently updated studies

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07187973

Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease

RecruitingPhase 2
Up to age 22 · All sexes · Updated Nov 12, 2026 · NCT07616154

HPC Offered for PRESERVE Expansion

RecruitingObservational study
Ages 12 to 80 · All sexes · Updated Nov 6, 2026 · NCT07145411

Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease

RecruitingPhase 4
Ages 18 to 50 · Women · Updated Nov 5, 2026 · NCT06665997

Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07224360

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Oct 28, 2026 · NCT07656415

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Oct 27, 2026 · NCT06546670

Blood Sampling for Research Related to Sickle Cell Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 26, 2026 · NCT00542230

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

RecruitingPhase 2
1 Day – 30 Years · All sexes · Updated Oct 23, 2026 · NCT04099966

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease

RecruitingPhase 1
Ages 13 to 35 · All sexes · Updated Oct 21, 2026 · NCT07708350

Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Oct 21, 2026 · NCT07566494

Virtual Reality for SCD VOC

Recruiting
Ages 18 to 88 · All sexes · Updated Oct 16, 2026 · NCT07674277

The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

RecruitingPhase 3
Ages 10 to 65 · All sexes · Updated Oct 15, 2026 · NCT06975865

Gene Editing For Sickle Cell Disease

RecruitingPhase 1
Ages 18 to 24 · All sexes · Updated Oct 15, 2026 · NCT06506461

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

RecruitingPhase 1/2
Ages 4 to 65 · All sexes · Updated Oct 13, 2026 · NCT07599176

Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting
Ages 16 to 39 · All sexes · Updated Oct 8, 2026 · NCT06374238

Exercise in Child Health

RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Oct 2, 2026 · NCT03937817

A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04055818

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

RecruitingEarly phase 1
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT06313398

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.