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Sickle Cell Disease clinical trials recruiting in the U.S.

107 studies for Sickle Cell Disease are recruiting participants at sites across the United States.

Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.

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Recently updated studies

Blood Sampling for Research Related to Sickle Cell Disease

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 29, 2026 · NCT00542230

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT03937817

A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 28, 2026 · NCT07656415

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

RecruitingEarly phase 1
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT06313398

A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226

Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 18, 2026 · NCT05170412

A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268

Tocilizumab for Acute Chest Syndrome

RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT05640271

Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)

RecruitingObservational studyHealthy volunteers welcome
Ages 12 and older · All sexes · Updated Sep 11, 2026 · NCT02824471

Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease

RecruitingObservational study
Ages 2 to 99 · All sexes · Updated Sep 11, 2026 · NCT06944067

Early Screening and Treatment of Heart Complication in Sickle Cell Disease

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07023666

A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

RecruitingPhase 1
Ages 8 to 17 · All sexes · Updated Sep 9, 2026 · NCT07226219

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06442761

Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors

RecruitingPhase 1/2
Ages 4 to 65 · All sexes · Updated Sep 4, 2026 · NCT07599176

Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults

RecruitingPhase 2
Ages 5 to 20 · All sexes · Updated Sep 2, 2026 · NCT07369024

Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Aug 24, 2026 · NCT07566494

Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography

RecruitingHealthy volunteers welcome
Ages 6 to 70 · All sexes · Updated Aug 20, 2026 · NCT07776444

A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

RecruitingPhase 2/3
Ages 12 and older · All sexes · Updated Aug 18, 2026 · NCT05431088

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders

RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.