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Sickle Cell Disease clinical trials recruiting in the U.S.
106 studies for Sickle Cell Disease are recruiting participants at sites across the United States.
Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.
Cities with the most studies
- Washington, DC21 studies
- Atlanta, GA20 studies
- Memphis, TN19 studies
- Chicago, IL18 studies
- New York City, NY16 studies
- Philadelphia, PA15 studies
- Birmingham, AL14 studies
- Houston, TX12 studies
- Boston, MA12 studies
- St. Louis, MO12 studies
- Durham, NC10 studies
- Cincinnati, OH10 studies
- Greenville, NC9 studies
- Columbus, OH9 studies
- Pittsburgh, PA9 studies
- Los Angeles, CA8 studies
- The Bronx, NY8 studies
- Baltimore, MD7 studies
- Charlotte, NC7 studies
- Cleveland, OH7 studies
- Oakland, CA7 studies
- Augusta, GA5 studies
- Detroit, MI5 studies
- Hartford, CT5 studies
- Jackson, MS5 studies
- Richmond, VA5 studies
- Phoenix, AZ5 studies
- Indianapolis, IN5 studies
- Nashville, TN5 studies
- Milwaukee, WI4 studies
- New Orleans, LA4 studies
- New Haven, CT4 studies
- Arlington, VA4 studies
- Greenville, SC4 studies
- Queens, NY4 studies
- Minneapolis, MN4 studies
- Greenburgh, NY3 studies
- Edison, NJ3 studies
- Mobile, AL3 studies
- Rochester, NY3 studies
By state
- Alabama16 studies
- Arizona5 studies
- Arkansas3 studies
- California19 studies
- Connecticut7 studies
- Delaware6 studies
- District of Columbia11 studies
- Florida9 studies
- Georgia23 studies
- Illinois19 studies
- Indiana5 studies
- Louisiana5 studies
- Maryland17 studies
- Massachusetts12 studies
- Michigan9 studies
- Minnesota6 studies
- Mississippi5 studies
- Missouri13 studies
- New Jersey8 studies
- New York23 studies
- North Carolina18 studies
- Ohio22 studies
- Pennsylvania20 studies
- South Carolina6 studies
- Tennessee22 studies
- Texas13 studies
- Virginia8 studies
- Wisconsin4 studies
Recently updated studies
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07187973Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
RecruitingPhase 2
Up to age 22 · All sexes · Updated Nov 12, 2026 · NCT07616154A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Nov 10, 2026 · NCT06439082HPC Offered for PRESERVE Expansion
RecruitingObservational study
Ages 12 to 80 · All sexes · Updated Nov 6, 2026 · NCT07145411Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
RecruitingPhase 4
Ages 18 to 50 · Women · Updated Nov 5, 2026 · NCT06665997Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Nov 5, 2026 · NCT05904093Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07224360A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Oct 28, 2026 · NCT07656415A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Oct 27, 2026 · NCT06546670Blood Sampling for Research Related to Sickle Cell Disease
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 26, 2026 · NCT00542230AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
RecruitingPhase 2
1 Day – 30 Years · All sexes · Updated Oct 23, 2026 · NCT04099966Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease
Recruiting
Ages 7 to 18 · All sexes · Updated Oct 22, 2026 · NCT07090668Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease
RecruitingPhase 1
Ages 13 to 35 · All sexes · Updated Oct 21, 2026 · NCT07708350Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 90 · All sexes · Updated Oct 21, 2026 · NCT07566494Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
RecruitingPhase 1/2
Ages 12 to 35 · All sexes · Updated Oct 20, 2026 · NCT04774536Virtual Reality for SCD VOC
Recruiting
Ages 18 to 88 · All sexes · Updated Oct 16, 2026 · NCT07674277The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
RecruitingPhase 3
Ages 10 to 65 · All sexes · Updated Oct 15, 2026 · NCT06975865Gene Editing For Sickle Cell Disease
RecruitingPhase 1
Ages 18 to 24 · All sexes · Updated Oct 15, 2026 · NCT06506461Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
RecruitingPhase 1/2
Ages 4 to 65 · All sexes · Updated Oct 13, 2026 · NCT07599176Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
Recruiting
Ages 16 to 39 · All sexes · Updated Oct 8, 2026 · NCT06374238Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Oct 8, 2026 · NCT06699849Exercise in Child Health
RecruitingHealthy volunteers welcome
Ages 10 to 17 · All sexes · Updated Oct 2, 2026 · NCT05359991Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Oct 2, 2026 · NCT03937817A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT04055818Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
RecruitingEarly phase 1
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT06313398From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.