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Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Recruiting

Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

Who can join

Ages 65 to 82 · All sexes

Full eligibility criteria
Inclusion Criteria:

* English or Spanish speaking
* Personal history of colorectal polyps
* Most recent colonoscopy with ≤2 non-advanced polyps
* Currently due or coming due within 12 months for colonoscopy
* Able to provide written informed consent

Exclusion Criteria:

* Personal history of colorectal cancer
* Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
* Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
* Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
* Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
* Patients unable to provide written informed consent

About the study

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

What is being tested

Sponsor: Dartmouth-Hitchcock Medical Center · Participants: 8,946 · Started: Jun 14, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT05612347

Locations in the U.S.

ArizonaUniversity of Arizona, Tucson
CaliforniaJennifer Moreno Department of Veterans Affairs Medical Cneter, San Diego
Kaiser Permanente Northern California, Walnut Creek
ColoradoUniversity of Colorado, Aurora
District of ColumbiaMedStar Health, Washington D.C.
FloridaJames A. Haley Veterans Hospital, Tampa
IllinoisNorthwestern Memorial Hospital, Chicago
IndianaRichard L. Roudebush VA Medical Center, Indianapolis
MichiganUniversity of Michigan Health, Ann Arbor
Henry Ford, Detroit
MissouriWashington University School of Medicine, St Louis
New HampshireDartmouth Health, Lebanon
New YorkNew York Harbor Health Care System - Dept of Veterans Affairs, New York
North CarolinaWake Forest University Health Sciences, Charlotte
OregonOregon Health & Science University (Knight Cancer Institute), Portland
UtahUniversity of Utah, Salt Lake City
Intermountain Health, Sandy City
VirginiaUniversity of Virginia Health, Charlottesville

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.