High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Who can join
Ages 65 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Ages 65 years and older * Male and female, any race * Medically cleared for exercise * Non-frail or pre-frail (frailty score \< 3) * Ability to use a recumbent exercise bike Exclusion Criteria: * Severe co-morbidity: COPD (GOLD stage IV), CKD ( stage 3)), severe HTN (180 mmHg/120 mmHg) * VA-SLUMS score 20 or lower (Cognition)
About the study
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems. Frailty leads to poorer physical performance and functional capacity and higher risk of adverse outcomes including falls, hospitalization, and mortality. Resilience, defined as the capacity to recover from disruptions to homeostasis, is critical to successful aging because it precedes frailty and enhances adults' ability to maintain optimal health and function well into older age. Evidence- based therapies to help older adults enhance resilience are limited and the biological underpinnings contributing to improved resilience have not yet been fully characterized. To address this important need, the investigators will conduct a clinical trial to examine the benefits of center- and home-based high intensity interval training (HIIT) on functional capacity, frailty, and resilience, and also to identify novel biomarkers of resilience in older Veterans.
What is being tested
- Center based attention (stretching only) control (behavioral)
- Center based HIIT (behavioral)
- Home based HIIT (behavioral)
Sponsor: VA Office of Research and Development · Participants: 200 · Started: Jan 29, 2024
Contact the study team
- Kenneth L Seldeen, PhD · Phone: (716) 888-4869
- Bruce R Troen, MD · Phone: (816) 922-2755
Official record on ClinicalTrials.gov — NCT05625204
Locations in the U.S.
| Missouri | Kansas City VA Medical Center, Kansas City, MO, Kansas City Kansas City VA Medical Center, Kansas City, MO, Kansas City (Not yet recruiting) |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.