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Wayfinding Intervention and Long-Term Memory
Virtual Reality Interventions to Stimulate Capabilities for Learning and Retrieval of High-Fidelity Memory
Who can join
Ages 60 to 85 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * fluent speakers of English * completed 12 or more years of education * normal or corrected-to-normal vision * dexterity to comfortably operate the scanner-compatible response box * freedom from physical and neurological conditions contra-indicated for fMRI * must confirm physical stamina and comfort for semi-weekly brisk 30-minute walks on level ground Exclusion Criteria: * use of psychotropic medications * history of concussions or dizziness, vestibular or balance problems * significant discomfort with virtual reality experiences
About the study
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment. Cognitive training with an immersive video game promises to drive hippocampal-cortical plasticity and associated gains that can restore memory capability or provide therapeutic treatment for memory deficits.
What is being tested
- LabyrinthVR software (behavioral)
- Placebo Games software (behavioral)
- Labyrinth Tablet software (behavioral)
- Labyrinth VR wireless (behavioral)
Sponsor: University of California, San Francisco · Participants: 200 · Started: Jan 1, 2024
Contact the study team
- Melissa Arioli · Phone: 415-502-7321
Official record on ClinicalTrials.gov — NCT05625425
Locations in the U.S.
| California | UCSF Mission Bay, San Francisco |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.