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Effects of Exercise on Dystonia Pathophysiology

Recruiting

Progressive Resistance Exercise and Dystonia Pathophysiology.

Who can join

Ages 30 to 85 · All sexes

Full eligibility criteria
Inclusion Criteria:

* Patients have predominantly focal cervical dystonia and whose diagnosis will be confirmed by a movement disorders specialist following criteria recommended by Movement Disorders Society.
* Moderate disease severity.
* Are 30 to 85 years old
* Are able to tolerate exercise sessions.
* Reporting suboptimal clinical benefits despite receiving maximally tolerated doses of BoNT injections for the neck muscles and/or oral pharmacological therapy.

Exclusion Criteria:

* Participating in an alternate structured exercise program, receiving regular physical or occupational therapy
* Have significant pain, spondylosis or active arthritis
* Fail the Physical Activity Readiness Questionnaire
* Have significant cognitive impairment
* Have implanted electrical device (eg, cardiac pacemaker or a DBS or a neurostimulator or metallic clip in their body, as necessitated by the risks of MRI or TMS
* Active seizure disorder; not be eligible for TMS and claustrophobic for MRI portion. As necessitated by the risks of MRI or TMS, patients who have any type of implanted electrical device (such as a cardiac pacemaker or a neurostimulator), or a certain type of metallic clip in their body (i.e., an aneurysm clip in the brain), active seizure disorder are not eligible for participation in the MRI or TMS portion of the study.
* Pregnancy tests will be carried out for each female subject of child bearing potential prior to the participation in the study and prior to each follow up visit (as indicated).

About the study

The purpose of this research study is to investigate how the brain and motor behavior changes in individuals with dystonia in response to exercise training.

What is being tested

Sponsor: University of Florida · Participants: 56 · Started: Oct 13, 2022

Contact the study team

Official record on ClinicalTrials.gov — NCT05663840

Locations in the U.S.

FloridaUniversity of Florida, Gainesville

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.