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Cardiac Power Output in Cardiogenic Shock Patients
RecruitingEarly phase 1
Myocardial Reserve in Advanced Heart Failure Patients
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: 1. LVEF ≤ 40% 2. Referred for RHC for: 1. Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR 2. Accurate assessment of invasive hemodynamics due to worsening clinical status, OR 3. Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR 4. Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI 3. Estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m2 4. Age ≥ 18 years-old 5. Intent for admission based on RHC data Exclusion Criteria: 1. eGFR \< 30 ml/min/1.73 m2 2. Severe, non-revascularized coronary artery disease 3. Concurrent acute coronary syndrome 4. Age \< 18 years-old 5. History of significant ventricular arrhythmia without an ICD
About the study
The main purpose of this study is to determine whether differences in myocardial reserve predict clinical outcomes for heart failure patients.
What is being tested
- 1:1 Randomization to receive milrinone (drug)
Sponsor: University of Chicago · Participants: 5 · Started: Jul 6, 2023
Contact the study team
- David Onsager, MD · Phone: 7737021000
Official record on ClinicalTrials.gov — NCT05700617
Locations in the U.S.
| Illinois | The University of Chicago, Chicago |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.