Home › Esophageal Cancer › NCT05706558

Retrospective Review of Esophageal Cancer at MSKCC

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

* Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy
* Pathologic staged T3 tumors (pT3)

Exclusion Criteria:

* Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4)
* Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion,
* Patients undergoing salvage esophagectomy
* Evidence of distant metastatic disease
* Patients with a positive proximal or distal margin

About the study

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

What is being tested

• Esophagectomy (procedure)

Sponsor: Memorial Sloan Kettering Cancer Center · Participants: 4,000 · Started: Dec 13, 2016

Contact the study team

• Daniela Molena, MD · Phone: 212-639-3870
• James Isbell, MD · Phone: 212-639-6247

Official record on ClinicalTrials.gov — NCT05706558

Locations in the U.S.

Conditions

• Esophageal Cancer

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.