Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment

Inclusion Criteria:

* African American
* age \>18 years
* interested in quitting
* smoked \>1 cpd for \>1 years
* smoked on \>25 days in the past month
* willing to take 6 months of study medication and complete all visits
* have a home address and functioning telephone number

Exclusion Criteria:

* Consistent with contraindications for bupropion:
* use of psychoactive medications
* history of alcohol or substance abuse within the past year
* binge drinking (\>5 drinks on one occasion) \>2 times in the past month
* history of seizures or head trauma; history of bulimia or anorexia nervosa
* pregnant (as measured by over the counter pregnancy test kit for women of child-bearing age only) or contemplating pregnancy; breast feeding
* myocardial infarction in the past 2 months
* reported use of opiates, cocaine, or stimulants
* unstable diabetes
* bupropion is a known inhibitor of the liver enzyme CYP2D6, so those taking drugs known to be higher metabolized by this enzyme (e.g., metoprolol, tamoxifen) will be excluded.
* use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days
* planning to move from the Kansas City area in the next year
* other smoker in household enrolled in the study.